임상약리학회지 (Journal of Korean Society for Clinical Pharmacology and Therapeutics)

대한임상약리학회 (Korean Society for Clinical Pharmacology and Therapeutics)
권호 표지

만성 간질환 치료 약제의 약물평가를 위한 객관적 검사모델 개발에 관한 연구(제 1 보) - HBsAg 건강보유자에서의 ICG-Rmax와 경직장 thallium-201 검사법(shunt index)에 관하여 -

Study of a Testing Model for Estimating the Efficacy of Drug for Chronic Liver Desease

  • 박문승 (???h양대학교 의과대학 내과학교실) ;
  • 황선호 (???h양대학교 의과대학 내과학교실) ;
  • 김목현 (???h양대학교 의과대학 내과학교실) ;
  • 김덕언 (한양대학교 의과대학 임상병리학교실) ;
  • 조석신 (한양대학교 의과대학 핵의학교실) ;
  • 이민호 (???h양대학교 의과대학 내과학교실)
  • Park, Mun-Seung (Department of Internal Medicine, Hanyang University, College of Medicine) ;
  • Hwang, Seon-Ho (Department of Internal Medicine, Hanyang University, College of Medicine) ;
  • Kim, Mok-Hyun (Department of Internal Medicine, Hanyang University, College of Medicine) ;
  • Kim, Duck-An (Department of Clinical Pathology, Hanyang University, College of Medicine) ;
  • Cho, Seok-Shin (Department of Nuclear Medicine, Hanyang University, College of Medicine) ;
  • Lee, Min-Ho (Department of Internal Medicine, Hanyang University, College of Medicine)
  • 발행 : 1996.12.30

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초록

Background : Analysis of variance of the intraindividuals with the ICG-Rmax and the per rectal thallium-201 liver scan (shunt index) is a way to find out their reproducibilities and also raises their utilities. Thus, it is considered as a facilitating evaluation of the drug effects in developing the remedies for the chronic liver disease. Method : The ICG-Rmax and the per rectal Thallium-201 liver scan (shunt index) were taken 3 and 4 times at week intervals for each 16 HBsAg healthy carrier confirmed by a liver biopsy. ANOVA was used as statistical method. Result : 1) The mean ${\pm}$ standard deviation of the shunt index and ICG-Rmax were $0.24\;{\pm}\;0.10$, $3.59\;{\pm}\;1.74\;mg/kg/min$. 2) The variance of the individuals in the whole group was calculated as 0.001 (p=0.884) with the shunt index, so there was no statistical significance. Also, there were no statistical significances in the male group (0.004, p=0.794) and the female group (0.0002, p=0.934). 3) The variance of the individual in the whole group was calculated as 9.127 (p=0.027) with the ICG-Rmax, so there was statistical significance. Additionally, there was statistical significance in the male group (6.573, p=0.032) but, not in the female group (3.755, p=0.401). 4) In shunt index, l1/16 patients lie between mean ${\pm}$ 1SD, and 15/16 patents lie between mean ${\pm}$ 2SD. In ICG-Rmax, 2/16 patients and 14/16 patients respectively. Conclusion : According to the results of the tests mentioned above, the reproducibility of the Thallium-201 liver scan is high but the that of ICG-Rmax is relatively low, compared to the former.

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