Journal of Korean Society for Clinical Pharmacology and Therapeutics (임상약리학회지)

Korean Society for Clinical Pharmacology and Therapeutics (대한임상약리학회)
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Study of a Testing Model for Estimating the Efficacy of Drug for Chronic Liver Desease

만성 간질환 치료 약제의 약물평가를 위한 객관적 검사모델 개발에 관한 연구(제 1 보) - HBsAg 건강보유자에서의 ICG-Rmax와 경직장 thallium-201 검사법(shunt index)에 관하여 -

  • Park, Mun-Seung (Department of Internal Medicine, Hanyang University, College of Medicine) ;
  • Hwang, Seon-Ho (Department of Internal Medicine, Hanyang University, College of Medicine) ;
  • Kim, Mok-Hyun (Department of Internal Medicine, Hanyang University, College of Medicine) ;
  • Kim, Duck-An (Department of Clinical Pathology, Hanyang University, College of Medicine) ;
  • Cho, Seok-Shin (Department of Nuclear Medicine, Hanyang University, College of Medicine) ;
  • Lee, Min-Ho (Department of Internal Medicine, Hanyang University, College of Medicine)
  • 박문승 (???h양대학교 의과대학 내과학교실) ;
  • 황선호 (???h양대학교 의과대학 내과학교실) ;
  • 김목현 (???h양대학교 의과대학 내과학교실) ;
  • 김덕언 (한양대학교 의과대학 임상병리학교실) ;
  • 조석신 (한양대학교 의과대학 핵의학교실) ;
  • 이민호 (???h양대학교 의과대학 내과학교실)
  • Published : 1996.12.30

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Abstract

Background : Analysis of variance of the intraindividuals with the ICG-Rmax and the per rectal thallium-201 liver scan (shunt index) is a way to find out their reproducibilities and also raises their utilities. Thus, it is considered as a facilitating evaluation of the drug effects in developing the remedies for the chronic liver disease. Method : The ICG-Rmax and the per rectal Thallium-201 liver scan (shunt index) were taken 3 and 4 times at week intervals for each 16 HBsAg healthy carrier confirmed by a liver biopsy. ANOVA was used as statistical method. Result : 1) The mean ${\pm}$ standard deviation of the shunt index and ICG-Rmax were $0.24\;{\pm}\;0.10$, $3.59\;{\pm}\;1.74\;mg/kg/min$. 2) The variance of the individuals in the whole group was calculated as 0.001 (p=0.884) with the shunt index, so there was no statistical significance. Also, there were no statistical significances in the male group (0.004, p=0.794) and the female group (0.0002, p=0.934). 3) The variance of the individual in the whole group was calculated as 9.127 (p=0.027) with the ICG-Rmax, so there was statistical significance. Additionally, there was statistical significance in the male group (6.573, p=0.032) but, not in the female group (3.755, p=0.401). 4) In shunt index, l1/16 patients lie between mean ${\pm}$ 1SD, and 15/16 patents lie between mean ${\pm}$ 2SD. In ICG-Rmax, 2/16 patients and 14/16 patients respectively. Conclusion : According to the results of the tests mentioned above, the reproducibility of the Thallium-201 liver scan is high but the that of ICG-Rmax is relatively low, compared to the former.

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