Korean Journal of Biological Psychiatry (생물정신의학)
- Volume 2 Issue 1
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- Pages.20-27
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- 1995
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
Measurement for Blood Levels of Psychotropics and Clinical Applications : Antidepressants
정신과약물의 혈중농도 측정방법 및 임상적 적용 : 항우울제를 중심으로
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Kim, Seung Hyun
(Department of Psychiatry. College of Medicine, Korea University) ;
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Lee, Min Soo
(Department of Psychiatry. College of Medicine, Korea University)
- Published : 1995.06.30
Abstract
Therapeutic montitoring of drugs is a well established clinical 1001. However, the state of art is somewhat less advanced for psychotrpoic agents than it is for other classes of drugs, for several reasons. Most psychotropics have large volumes of distribution and achieve relatively low plasma concentrations following therapeutic doses. Many have one or more active metabolites. As a consequene, the analytical methodologies are often complex and not always reliable; well-controlled clinical studies are difficult to perform; and therapeutic ranges have been difficult to establish. Despite these limitations, prudent and selective monitoring of serum drug concentrations, particularly of the tricyclic antidepressants can be helpful in clinical management. This paper presents an overview of clinical and mothodological issues surrounding the utility of blood level measurement.