Clinical and Experimental Reproductive Medicine
- Volume 22 Issue 2
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- Pages.203-210
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- 1995
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- 2233-8233(pISSN)
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- 2233-8241(eISSN)
Chromosomal Abnormalities in Human Oocytes Fail to Fertilize after Insemination In Vitro
수정에 실패한 인간 난자에 있어서의 염색체의 수의 이상
- Son, Weon-Young (Infertility Medical Center, Genetics Laboratory, Cha General Hospital) ;
- Lee, Kyung-Ah (Infertility Medical Center, Genetics Laboratory, Cha General Hospital) ;
- Park, Sang-Hee (Infertility Medical Center, Genetics Laboratory, Cha General Hospital) ;
- Han, Sei-Yul (Infertility Medical Center, Genetics Laboratory, Cha General Hospital) ;
- Yoon, Tae-Ki (Infertility Medical Center, Genetics Laboratory, Cha General Hospital) ;
- Jung, Hyung-Min (Infertility Medical Center, Genetics Laboratory, Cha General Hospital) ;
- Kwak, In-Pyung (Infertility Medical Center, Genetics Laboratory, Cha General Hospital) ;
- Cha, Kwang-Yul (Infertility Medical Center, Genetics Laboratory, Cha General Hospital)
- 손원영 (차병원 여성의학연구소) ;
- 이경아 (차병원 여성의학연구소) ;
- 박상희 (차병원 여성의학연구소) ;
- 한세열 (차병원 여성의학연구소) ;
- 윤태기 (차병원 여성의학연구소) ;
- 정형민 (차병원 여성의학연구소) ;
- 곽인평 (차병원 여성의학연구소) ;
- 차광열 (차병원 여성의학연구소)
- Published : 1995.08.30
Abstract
Many oocytes fail to fertilize and cleave in vitro and many embryos transferred back to uterus fail to implant or maintain implantation. Chromosomal abnormalities in the male and female gametes may contribute to this loss. The higher incidence of meiotic chromosomal abnormalities bas been found in oocytes than in sperm. The wide range of incidence of chromosomal abnormalities in unfertilized oocytes has been reported in human IVF program (26-63%). However, factors affecting chromosomal abnormalities are not well understood. The present study has been conducted to investigate effects of the method for ovarian hyperstimulation, women's age, and the number of oocytes retrieved per patients on the incidence of numerical chromosomal abnormalities. Five hundred eighty four unfertilized metaphase II oocytes were subjected to chromosomal analysis. Included unfertilized oocytes were from 220 patients (mean
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