Embryonic Effects of Ultrasound Irradiation on Preimplantation Stage of ICR Mouse Embryos - About embryonic death and malformation of ultrasound mechanisms -

초음파(超音波)에 대한 ICR Mouse 착상전기(着床前期)의 개체(個體) Level 영향(影響)(기형(奇形).배사망.(胚死亡))으로부터 초음파(超音波)의 물리학적(物理學的) 특성(特性)에 대한 연구(硏究)

Embryos and fetuses are more sensitive to various environmental agents than adults of children biological effects following the exposure, such as intrauterin, malformation, have intimate conception with the prenatal exposure. There have been many studies on radiation and other agent. However, imformation about the ultrasound effects is limited. It is very important to study the effect of ultrasound with these kinds of fatera in consideration of ultrasound protection and safty. In this study, embryonic and fefal effects of ICR mouse embryos irradiated on 24, 48, 12 and 192 hpc of preimplantation and organogenesis period at the intensity of $0.5{\sim}3\;W/cm^2$ were investigated. Many type of external malformation observed in mouse irradiated on 72 hpc and 192 hpc. However, the embryos irradiated on 24 hpc and 48 hpc, at witch embryos had less then 6 cells and were pre-compaction stage, had no sensitivity for external malformation. The threshold doses of external malformation in mouse irradiated on 72 hpc and 192 hpc, at which embryos were consisted of $16{\sim}32$ cells and neural formation stage, were $1\;W/cm^2$ and $0.5\;W/cm^2$.