The Korean Journal of Pain

The Korean Pain Society (대한통증학회)
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Effects of Ketamine on the Causalgiform Pain Produced by the Tight Ligation Of L5, L6 Spinal Nerves in the Rat

백서에서 제 5, 6번 요추신경의 결찰에 의하여 유발된 작열통성 통증에 대한 Ketamine의 치료효과

  • Lee, Won-Hyung (Department of Anesthesiology, College of Medicine, Chungnam National University) ;
  • Han, Neung-Hee (Department of Anesthesiology, College of Medicine, Chungnam National University) ;
  • Kim, Tae-Heon (Taecheon and Kim Tae Heon Clinic)
  • 이원형 (충남대학교 의과대학 마취과학교실) ;
  • 한능희 (충남대학교 의과대학 마취과학교실) ;
  • 김태헌 (김태헌의원)
  • Published : 1995.04.15
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Abstract

We produced the causalgiform pain by the tight ligation of L5 and L6 spinal nerves in the adult rats. To evalute the effect of Ketamine -noncompetitive NMDA (N-methyl-D aspartate) antagoinst- on the causalgiform pain, we tested the changes of; withdrawal sensitivity to the innocuous mechanical stimulation of Von Frey hair 2.35 g(mechanical allodynia); withdrawal frequency to the cold stimulation of acetone (cold allodynia); and total withdrawal time (second) to the cold ($4^{\circ}C$) plate stimulation (cold hyperalgesia) after the administration of 1 mg, 3 mg, 10 mg/kg ketamine. The results were as follows: 1) Cold hyperalgesia was significantly reduced (p<0.05) by 1 mg, 3mg, 01 mg/kg ketamine. 2) Cold allodynia and mechanical allodynia was significantly reduced (p<0.05) by 10 mg/kg ketamine. Above results suggest a therapeutic utility of ketamine in treatment of causalgia - especially, cold hyperalgesia.

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