Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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Neurobehavioral Changes according to Cumulative Exposure of Complex Organic Solvents

복합유기용제의 누적 폭로 정도에 따른 신경행동학적 변화

  • Lee, Duk-Hee (Department of Preventive Medicine, Kosin College of Medicine) ;
  • Park, In-Geun (Department of Preventive Medicine, Kosin College of Medicine) ;
  • Kim, Jin-Ha (Department of Preventive Medicine, Kosin College of Medicine) ;
  • Lee, Young-Hawn (Department of Preventive Medicine, Kosin College of Medicine) ;
  • Kang, Sung-Gye (Industrial Health Research Institute) ;
  • Kim, Doo-Hie (Department of Preventive Medicine, College of Medicine, Dongguk University)
  • 이덕희 (고신대학교 의학부 예방의학교실) ;
  • 박인근 (고신대학교 의학부 예방의학교실) ;
  • 김진하 (고신대학교 의학부 예방의학교실) ;
  • 이용환 (고신대학교 의학부 예방의학교실) ;
  • 강성규 (산업보건연구원) ;
  • 김두희 (동국대학교 의과대학 예방의학교실)
  • Published : 1995.06.01
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Abstract

A cross sectional study was performed to evaluate the neurobehavioral effects of chronic exposure of complex organic solvents, using NCTB(Neurobehavioral Core Test Battery) recommended by WHO(World Health Organization). Forty female shoe factory workers and twenty-two controls matched with age were participated. The tests were performed in the morning before start of work, to exclude the effects of acute exposure. Workers were exposed mainly to toluene, methyl ethyl ketone, n-hexane, cyclo-hexane, dichloroethylene, trichloroethylene, benzene, xylenes etc. The ranges of present solvent exposure of hygienic effect were $0.46\sim0.71$ in the process using adhesives indirectly, and $1.83\sim2.39$ in the process using it directly. We reclassified the subjects, according to cumulative exposure. It showed significantly poorer performances in high exposed group on Santa Ana Dexterity and Benton Visual Retention, compared with control group. After controlling confounder, the significances were still remained. But, further cohort studies, having the information of personal exposure dose from entering a factory, are required to clarify the effects of chronic exposure of complex organic solvents in relation to dose and duration of exposure.

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