Journal of Periodontal and Implant Science
- Volume 25 Issue 2
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- Pages.438-457
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- 1995
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- 2093-2278(pISSN)
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- 2093-2286(eISSN)
THE IMMUNOCYTOCHEMICAL STUDY OF THE PRECURSOR CELLS IN THE PERIODONTAL REGENERATION OF HORIZONTAL FURCATION DEFECT.
치근이개부 수평결손시 조직재생에 관여하는 전구세포의 면역세포화학적 연구
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Herr, Yeek
(Department of Periodontology, College of Dentistry, Kyung-Hee University) ;
- Kwon, Young-Hyuk (Department of Periodontology, College of Dentistry, Kyung-Hee University)
- Published : 1995.07.31
Abstract
The origin of fibroblasts, their proliferative activity and roles in the early stages of periodontal regeneration were investigated in order to better understand the periodontal healing process in furcation defects of the beagle dog after guided tissue regeneration. Newly divided cells were identified and quantitated by immunolocalization of bromodeoxyuridine (BrdU) injected 1 hour prior to sacrificing the animals. The results were as follows :1. During periodontal healing in horizontal furcation defect, three different stages, namely the granulation tissue, connective tissue, and bone formation stages, were identified on the basis of major types of cells and tissue. 2. In the early stages of periodontal regeneration, both the remaining periodontal ligament and alveolar bone compartment were the major sources. 3. The majority of BrdU-labeled fibroblasts were located at the following areas ; 1) the coronal zone of the defect in case of the connective tissue fanned on the root surface. 2) the area within an 400
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