Sleep Medicine and Psychophysiology (수면정신생리)
- Volume 2 Issue 2
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- Pages.156-164
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- 1995
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- 1225-7354(pISSN)
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- 2713-8631(eISSN)
The Changes of Plasma Atrial Natriuretic Peptide Concentrations During Waking and Sleep in Patients with Obstructive Sleep Apnea Syndrome
폐쇄성 수면 무호흡증후군 환자에서 각성시와 수면중의 혈중 Atrial Natriuretic Peptide 농도 변화
- Moon, Hwa-Sik (Department of Internal Medicine, Catholic University Medical College) ;
- Choi, Young-Mee (Department of Internal Medicine, Catholic University Medical College) ;
- Song, Jeong-Sup (Department of Internal Medicine, Catholic University Medical College) ;
- Park, Sung-Hak (Department of Internal Medicine, Catholic University Medical College)
- 문화식 (가톨릭대학교 의과대학 내과학교실) ;
- 최영미 (가톨릭대학교 의과대학 내과학교실) ;
- 송정섭 (가톨릭대학교 의과대학 내과학교실) ;
- 박성학 (가톨릭대학교 의과대학 내과학교실)
- Published : 1995.12.31
Abstract
Objectives : Patients with obstructive sleep apnea syndrome(OSAS) often complain of nocturnal enuresis. There are a few reports that OSAS patients have altered renal function, and there are some evidences that the increased release of atrial natriuretic peptide(ANP) may be involved in the pathogenesis of nocturnal urinary symptoms of OSAS patients. In this study, we measured plasma ANP concentrations during waking and sleep in OSAS patients and normal controls to investigate whether there were differences of ANP concentrations between OSAS patients and normal subjects. Methods : 27 patients with OSAS and 10 normal subjects were studied. All subjects underwent a full-night polysomnographic study. Venous blood samples were separately drawn during waking and sleep. Plasma ANP concentrations were measured using radioimmunoassay. Results : In OSAS patients, ANP concentrations during sleep(
폐쇄성 수면 무호흡증후군 환자는 정상인과 달리 각성시보다 수면중에 뇨량과 나트륨 뇨배설이 증가하며 이러한 현상은 atrial natriuretic peptide(ANP)의 분비반응과 관련이 있을 것으로 보고된 바 있다. 저자들은 수면다원검사를 통해 폐쇄성 수면 무호흡증후군으로 확진된 환자군과 정상 대조군을 대상으로 각성시와 수면중에 말초 정맥혈로부터 혈중 ANP 농도를 측정하여 다음과 같은 결과를 얻었다. 1) 폐쇄성 수면 무호흡증후군 환자군에서는 수면전 ANP 농도 (