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Modified LOGIT(MLOGIT) Transformation: Prediction of $IC_{50}$ Value from Two Arbitrary Concentration Data

  • Published : 19950200

Abstract

A LOGIT transformation is a method to estimate IC50 values with two arbitrary concentration data when complete dose response curves(DRCs) are not available. We propose a modified LOGIT transformation (MLOGIT) which predicts IC50 values more accurately than the conventional LOGIT method.

Keywords

References

  1. J. Pharmacol. Meth. v.13 McPherson, G. A.
  2. J. Pharmacochem. Libr. v.10 Schaper, K.
  3. SYBYL 6.0 Manual
  4. J. Med. Chem. v.16 Fuller, R. W.;Molloy, B. B.;Day, W. A.;Roush, B. W.;Marsh, M. M.