Biomolecules & Therapeutics
- 제3권2호
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- Pages.111-115
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- 1995
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- 1976-9148(pISSN)
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- 2005-4483(eISSN)
황련추출물에 의한 HIV-1 복제 저해
Inhibition of HIV-1 Replication by Extract of Coptis chinensis
초록
Natural products, total number of 175, were screened to test for their effect on the replication of human immunodeficiency virus type 1 (HIV-1). Five of them, such as Eriobotrya japonica, Eugenia caryphyllata, Cuscuta chinensis, Glycyrrhiza uralensis, and Coptis chinensis were shown to be effective in inhibiting the replication of HIV-1 in tissue culture and their selectivity indexes were 42, 40, 14, 18 and 65, respectively. To further fractionate Coptis chinensis, which is shown to be highest anti-HIV-1 activity, methanol extracts of Coptis chinensis were fractionated into methylene chloride at pH3, pH10 and water residue. The selectivity Indexes of CH
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