Biomolecules & Therapeutics
- 제3권2호
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- Pages.97-103
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- 1995
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- 1976-9148(pISSN)
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- 2005-4483(eISSN)
흰쥐에서의 신규 항암제 BR-28702-2의 체내동태
Pharmacokinetic Study on BR-28702-2, a New Anticancer Drug, in Rats
초록
The purpose of this study was to determine pharmacokinetic parameters of BR-28702-2, a new antineoplastic agent which is the conjugate of nucleotide and phospholipid, and to compare them with those of ara-C. Male rats were cannulated in the left femoral vein and received a single i.v. bolus dose of either BR-28702-2 or ara-C. BR-28702-2 was also administered i.p. and plasma samples were analyzed by reversedphase HPLC. The t
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