Environmental Analysis Health and Toxicology
- Volume 10 Issue 3_4
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- Pages.1-5
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- 1995
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- 2671-9525(eISSN)
General Toxicity of Novel Pt(II) Complexes in vivo
새로운 항암성 백금(II) 착체류의 in vivo 독성 연구
Abstract
The general toxicological study of new platinum(II) compounds, KHPC-002, KHPC-005 and KHPC-006 were investigated in rats. The effects of these Pt(II) complexes on renal, hematopoietic and hepatic system in rats showed lower toxicity compared with cisplatin. In the consideration of the maximal dose of these Pt(II) complexes using in this experiment is 4-8 times higher than cisplatin, these novel compounds will have the less general toxicity in vivo.
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