A Phospholipase $A_2$ Inhibitor Isolated from Umilicaria esculenta

Umbilicaria esculenta가 생산하는 Depside계 화합물의 구조 및 Phospholipase $A_2$ 저해활성

  • 김진우 (한국과학기술연구원 생명공학연구소) ;
  • 송경식 (경북대학교 농화학과) ;
  • 장현욱 (영남대학교 약학대학) ;
  • 유승헌 (충남대학교 농생물학과) ;
  • 유익동 (한국과학기술연구원 생명공학연구소)
  • Published : 1995.10.01

Abstract

Phospholipase A$_{2}$ (PLA$_{2}$) is lipolytic enzyme that has known to be involved in inflammation. In the course of our screening for antiinflammatory compounds from natural products, a compound having PLA$_{2}$ inhibitory activities was isolated from the methanol extract of Umbilicaria esculenta. The compound was identified as lecanoric acid based on various NMR studies including DEPT, HETERO-COSY and HMBC experiments. Lecanoric acid inhibited human rheumatoid synovial PLA$_{2}$ activity with IC$_{50}$ of 0.17 mM and also exhibited antitumor activity (ED$_{50}$=2.7 $\mu $g/ml) against skin tumor cell line (LOX-IMVI).

Keywords

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