Journal of Microbiology

The Microbiological Society of Korea (한국미생물학회)
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Molecular cloning and nucleotide sequence of schizosaccharomyces pombe Homologue of the receptor for activated protein kinase C gene

  • Published : 1995.06.01
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Abstract

Using differential hybridization, we selected the prk gene fortuitously from Schizosaccharomyces pombe homologous to RACK1 of rat which encodes the receptor for activated protein kinase C. The cDNA sequence of prk was determined and its deduced amino acid sequence was 76% homologous to RACK1 and had the feature of trimeric G protein bata subunit. The specific amino acid sequences required for the protein kinase C binding were also present in Prk as in the case of RACK1 protein. From these similarities, we suggest that the Prk is protein kinase C binding protein of S. prombe. The involvement of Prk in signal transduction mediated by protein kinase C remained to be studied.

Keywords

References

  1. Nature v.344 Kinase and neurotransmitters Aitken,A.;C.A.Ellis;A.Harris;L.A.Sellers;A.Toker
  2. J. Immunol. v.138 Transmembrane signaling through B cell MHC class Ⅱ molecules: anti-Ia antibodies induce protein kinase C translocation to the nuclear fraction protein kinase associated with plasma membrane Chen,Z.Z.;J.C.McGuire;K.L.Leach;J.C.Cambier
  3. Proc. Natl. Acad. Sci. v.91 Phospholipase C-γ1 binding to intracellular receptors for activated protein kinase C Disatnik,M.H.;S.M.T.Hernandez-Sotomayor;G.Jones;G.Carpenter;D. Mochly-rosen
  4. J. Biol. Chem. v.264 Interleukin-3 and bryostatin 1 mediate rapid nuclear envelope protein phosphorylation in growth factor-dependent FDC-P1 hematopoietic cells:A possible role for nuclear proteir kinase C Fields,A.P.;S.M.Pincus;A.S.Kraft;W.S.May
  5. J. Biol. Chem. v.261 Factors influencing chelator-stable, detergent-extractable, phorbol diester-induced membrane association of protein kinase C Gopalakrishma,R.;S.H.Barsky;T.P.Thomas;W.B.Anderson
  6. J. Biol. Chem. v.262 Protein kinase C in fibroblast Halsey,D.L.;P.R.Girard;J.F.Kuo;P.J.Blackshear
  7. Biochem. Biophys. Res. Common. v.160 Possible involvement of microfilaments in protein kinase C translocation Ito,M.;F.Tanabe;A.Sato;E.Ishida;Y.Takami;S.Shigeta
  8. J. Cell. Biol. v.109 A association of type 3 protein kinase C with focal contacts in rat embryo fibroblasts Jaken,S.;K.Leach;T.Klauck
  9. Nature v.301 Phorbol esters increase the amount of $Ca^{2+}$ phospholipid-dependent protein kinase associated with plasma membrane Kraft,A.S.;W.B.Anderson
  10. J. Cell Biol. v.116 Mutations in the Saccharomyces cerevisiae PKC1 gene display a cell cycle-specific osmotic stability defect Levin,D.E.;E. Bartlett-Heubusch
  11. Cell v.62 A candidate protein kinase C gene, PKC1, is required for the Saccharomyces cerevisiae cell cycle Levin,D.E.;F.O.Fields;R.Kunisawa;J.M.Bishop;J.Thorner
  12. Proc. Natl. Acad. Sci. v.88 Identification of intracellular receptor proteins for activated protein kinase C Mochly-Rosen;D.;H.Khaner;J.Lopez
  13. J. Biol. Chem. v.266 Intracellular receptors for activated protein kinase C Mochly-Rosen,D.;H.Khaner;J.Lopez;B.L.Smith
  14. Biochemistry v.31 fragment, homologous to the C2 region of protein kinase C, binds to the intracellular receptors for protein kinase C Mochly-Rosen, D.;K.G.Miller;R.H.Scheller;H.Khaner;J.Lopez;B.L.Smith
  15. Nature v.308 The role of protein kinase C in cell surface transduction and tumour promotion Nishizuka,Y.
  16. Nature v.334 The molecular heterogeneity of protein kinase C and its implicationsfor cellular regulation Nishizuka,Y.
  17. Science v.258 Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C Nishizuka,Y.
  18. Kor. Jour. Microbiol. The isolation of cell cycle specific genes from fission yeast Schizosaccharomyces pombe by differential hybridization Park,S.K.;H.S.Yoo
  19. Proc. Natl. Acad. Sci. v.89 Membrane-bound Dictyostelium myosin heavy chain kinase A: developmentally regulated substrate-specific member of the protein kinase C family Ravid.S.;J.A.Spudich
  20. Proc. Natl. Acad. Sci. v.91 Cloning of an intracellular receptor for protein kinase C: A homolog of the β subunit of G proteins Ron,D.;C.H.Chen;J.Caldwell;L.Jamieson;E.Orr;D.Mochly-Rosen
  21. Biochem. Biophys. Res. Commun. v.188 Inhibition of protein kinase C function by injection of intracellular receptors for the enzyme Smith,B.L.;D.Mochly-Rosen
  22. EMBO J. v.12 Two novel protein kinase C-related genes of fission yeast are essential for cell viability and implicated in cell shape control Toda,T.;M.Shimanuki;M.Yanagida