References
- Vaccine v.6 Development of inactivated vaccine against virus causing hemorrhagic fever with renal syndrome Koichi Yamanishi(et al.)
- 국립보건안전연구원 고시 제 94-3호 의약품등의 독성 시험 기준 국립 보건 안전 연구원
HRccine(HFRS-virus vaccine) was administered subcutaneously or intragastrically to Spargue Dawley rats and subcutaneously to Japanese white rabbits to investigate the acute toxicity. $LD_50$ values were above 600 times the expected clinical dose in both animals. There were no differences in body weight changes, clinical signs and autopsy findings between all treated groups and control group in both animals. Therefore, it was concluded that HRccine is a very safe substance.