Journal of Chest Surgery

  • 제28권12호
  • /
  • Pages.1096-1106
  • /
  • 1995
  • /
  • 2765-1606(pISSN)
  • /
  • 2765-1614(eISSN)
대한심장혈관흉부외과학회 (The Korean Society for Thoracic and Cardiovascular Surgery)
권호 표지

일측 폐이식 실험견에서 이식폐의 기능 평가연구

An Assessment of Allograft Function in Canine Single Lung Transplantation

  • 발행 : 1995.12.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

We experienced 7 cases of left single lung transplantation in 14 mongrel dogs and analyzed graft lung function by hemodynamics, blood gas analysis, chest X-ray, biopsy and perfusion lung scan. We performed right pulmonary artery cuff[PA cuff for analysis of graft lung function in 3 cases. The donor lungs were flushed with modified Euro-Collins solution[n=3 or low potassium dextran glucose solution[n=4 and preserved for 4 to 5 hours[n=4 or 24 hours[n=3 at 10o C and implanted to the dogs with similar weight . Assessment of left graft lung was done by occluding the right pulmonary artery for 10 minutes using PA cuff. Assessment for graft lung function was done immediately after an operation and after 3 days, 7days and 3 weeks postoperatively. Four dogs survived for 3days, 7days[2 cases and 3 weeks respectively. Other three dogs expired within 3 hours of reperfusion. Immediate perfusion scans of left lung in four survived dogs after reperfusion were 42.1%, 36% , 11% and 5.9% respectively, and another dog with 4.8% perfusion to left lung was dead due to left atrial thrombi after 3 hours reperfusion. In one case among three acute rejections follow-up perfusion scan was done on 3rd and 11th postoperative day and the result decreased from 36% perfusion immediate postoperatively to 21% and 15% respectively. Three expired dogs postoperatively couldn`t tolerate occlusion of right pulmonary artery with above 40 mmHg of mean pulmonary artery pressure. On the other hand, three survival dogs postoperatively tolerated occlusion of right pulmonay artery with less than 30 mmHg of mean pulmonary artery pressure. and one dog couldn`t tolerate same procedure immediate postopertively but in 2 hours reperfusion later tolerated with 29 mmHg of mean pulmonary artery pressure.In conclusion we couldn`t compare the effect of two flushing solutions but low potassium dextran glucose solution showed relatively safe preservation effect in cases with preservation of more than 20 hours. Also canine left single lung transplantation model with PA cuff indicated useful method for the assessment of graft lung function with effect of lung preservation.

키워드

참고문헌

  1. Ann Thorac Surg. v.56 Lung preservation with low- potassium dextran flush in a primate bilateral transplant model Sundaresan,S.;Lima,O.;Date,H.(et al.)
  2. 대흉외지 v.27 황견에서 좌측 폐이식 수술 및 우측 폐동맥결찰 수술후 폐동맥압 변화에 관한 연구 이두연;배기만;백효채;박만실;이원영
  3. J Thorac Cardiovasc Surg. v.103 In a canine model, lung preservation at 10°C is superior to that at 4°C. A comparison of two preservation temperatures on lung function and on adenosine triphosphate level measured by phosphourus-31 nuclear magnetic resonance. Date,H.;Lima,O.;Matsumura,A.(et al.)
  4. Experimental Transplantation of vital Organs. Demilhov,V.P.
  5. C R Acad Sci v.231 Note preliminaire sur la greffe totale du poumonchez le chien Metra,H.
  6. Adv Surg v.2 Lung transplantation Hardy,J.D.;Alican,F.
  7. J Thorac Surg v.21 Pneumonectomy with replantation of the lung in the dog for physiologic study Juvenelle,A.A..;Ciret,C.;Wiles,C.E.(et al.)
  8. J Thorac Cardiovasc Surg v.46 Autotransplantation and homotransplantation of the lung : Further studies. Hardy,J.D.;Eraslan,S.;Dalton,M.L.
  9. JAMA v.186 Lung homotransplantation in man Hardy,J.D.;Webb,W.R.;Dalton,M.L.(et al.)
  10. J Thorac Cardiovasc Surg. v.61 Ten month survival after lung homotransplantation in man Derom,F.;Barbier,F.;Ringoir,S.(et al.)
  11. J Thorac Cardiovasc Surg. v.82 Effects of methylprednisolone and azathioprine on bronchial healing following lung transplatation Lima,O.;Cooper,J.D.;Peters,W.J.(et al.)
  12. J Thorac Cardiovasc Surg. v.83 Bronchial omentopexy in canine lung transplantation. Lima,O.;Goldberg,M.;Peters,W.J.(et al.)
  13. Can J Surg. v.13 Bronchial arterial circulation restored after reimplantation of canine lung Pearson,F.G.;Goldberg,M.;Stone,R.M.(et al.)
  14. Surg Forum v.17 Bronchial artery regeneration after radical hilar stripping Stone,R.M.;Ginsberg,R.J;Colapinto,R.F.(et al.)
  15. Transplant Proc. v.23 Current status of lung transplantation Cooper,J.D.
  16. J Thorac Cardiovasc Surg. v.101 Single lung transplantation-alternative indications and techniques Calhoon,J.H.;Grover,F.L.;Gibbons,W.J.(et al.)
  17. Eur Urol v.6 Forty-eight to 96 hour preservation of canine kidneys by initial perfusion and hypthermic storage using the Euro-Collins solution Dreikorn,K.(et al.)
  18. Transplantation v.43 Successful 72 hour preservation of the canine pancres Wahlberg,J.A.;Love,R.;Landegaard,I.(et al.)
  19. Transplantation reviews v.3 The University of Wisconsin Solutionfor organ preservation. Southard,J.H.;Pienaar,H.;Mcanulty,J.F.(et al.);Morris,P.J;Tilney,N.L.(ed.)
  20. J Heart Transplant v.5 Successful six hour cardiopulmonary preservation with simple hypothermic crystalloid flush Starkey,T.D.;Sakakibara,N.;Hagberg,R.C.(et al.)
  21. J Heart Transplant v.5 Flush perfusion using Euro-Collins solution vs cooling by means of extra-corporeal circulation in heart-lung preservation Wahler,T.;Haverich,A.;Fieguth,H.G.(et al.)
  22. Transplantation v.49 The superiorty of an extracellular fluid solution over Euro-Collins solution for pulmonary preservation Yamazaki,F.;Yokomise,S.;Schreinemakers,H.(et al.)
  23. J Thorac Cardiovasc Surg. v.103 no.1 Comparison of the University of Winsconsin preservation solution and other crystalloid perfusates using a 30 hour rabbit preservation model. Miyoshi,S.;Shimokawa,S.;Schreinemakers,H.(et al.)
  24. Transplant v.35 Prostaglandin as an effetive antirejection therapy in rat renal allograft recipients. Strom,T.B.;Carpenter,C.B.
  25. J Thorac Cardiovasc Surg. v.101 Influence of intraalveolar oxygen concentration on lung preservation in a rabbit model. Weder,W.;Harper,B.;Shimokawa,S.(et al.)
  26. J Thorac Cardiovasc Surg. v.98 Are temperatures attaine by donor hearts during tansport too cold? Hendry,P.J.;Walley,V.M.;Koshal,A.(et al.)
  27. Surg Gynecol Obstet v.25 Respiratory fuction following cardiopulmonary denervation in dog,cat, and monkey. Nakae,S.;Webb,W.R.;Theodorides,T.(et al.)
  28. J Heart Lung Transplant v.13 Euro-Collins flush perfusion in human lung preservation-ultrastructural strudies of the preservation quality of the contralateral donor lung in clinical single lung transplantation Fehrenbach,H.;Hirt,S.W.;Wahlers,T.(et al.)
  29. J Korean Medical Science v.8 no.3 Early allograft function in canine single lung transplant Sohn,K.H.;Song,M.G.;Lee,J.M.(et al.)
  30. 대흉외지 v.24 한국산 잡견에서의 단일 폐이식술에 관한 실험적 연구(Ⅰ) 김주현;송현;박계현;조상록;이정상;김기봉;성숙환;김종환
  31. Ann Thorac Surg. v.59 Successful canine bilateral single-lung transplantation after 21-hour lung preservation. Date,H.;Izumi,S.;Miyade,Y.(et al.)