Journal of Chest Surgery

The Korean Society for Thoracic and Cardiovascular Surgery (대한심장혈관흉부외과학회)
권호 표지

Experimental Evaluation of Algin-coated Vascular Grafts in Dogs

잡견에서의 알진 코팅 인조혈관 삽입실험

  • 김원곤 (서울의대, 한남대학 이과대학, °)
  • Published : 1995.06.01
Download PDF
⟨ Previous Next ⟩

Abstract

Microvel knitted double velour vascular grafts coated with biodegradable algin were evaluated in the canine experimental model as a new biologically coated Dacron graft. Three series of implantations were conducted involving the insertion of 6 mm diameter grafts in the abdominal aortae of mongrel dogs. The first series used the regular Microvel vascular grafts coated with algin,whereas the second and third series used Hemashield [collagen-coated grafts and the regular Microvel grafts with preclotting,respectively as control groups. Each series involved the implantation of one prosthesis for each of 2 preselected periods,namely 3 months and 6 months. In addition,algin-impregnated grafts were implanted for 4 hours,72 hours,2 weeks,and 4 weeks. All grafts were patent when the animals were sacrificed at intervals ranging from 4 hours to 6 months. Histological examinations revealed no obvious or significant differences in the healing characteristics of the algin-coated grafts and the control grafts after 3 months and 6 months of implantation. Endothelial cell-like cells were present on the midsegments of all grafts explanted from animals sacrificed after 3 months and 6 months,except a suspicious finding in the 3 month-implantation animal of a preclotted graft. With special stains,the algin became invisible between the polyester filaments during the first 3 months of implantation. This study has demonstrated that the use of a biodegradable algin coating is a feasible approach as biological sealants for textile arterial prostheses.

Keywords

References

  1. Vascular Surgery(4th ed.) Prosthetic grafts Brewster,D.C.;Rutherford,R.B.(ed.)
  2. Arch Surg v.88 Importance of porosity in arterial prosthesis Fry,W.J.;DeWeesse,M.S.;Kraft,R.O.;Ernst,C.B.
  3. Trans ASAIO v.34 The effect of porosity and biomaterial on the healing and long-term mechanical properties og vascular prostheses White,R.A.
  4. Vascular Surgery(4th ed.) Vascular grafts Kempczinski,R.F.;Rutherford,R.B.
  5. Ann Surg v.188 The preclotting of porous arterial prostheses Yates,S.G.;Barros,A.A.B.;Berger,K.(et al.)
  6. Circulation v.66 no.SUP.1 A comparison of preclotting techniques for prosthetic aortic replacement Thurer,R.L.;Hauer,J.M.;Weintraub
  7. Biomaterials v.10 Effect of preclotting of porosity and thrombogenicity of knitted Dacron grafts Sheehan,S.J.;Rajah,S.M.
  8. Am Surg v.54 Early experience with a new collagen-impregnated aortic graft Reigel,M.M.;Hollier,L.H.;Pairolero,P.C.;Hallett,J.W.
  9. Biomaterials v.10 Collagen coatings as biological sealants for textile arterial pros theses Guidoin,M.;Marceau,D.;Couture,J.(et al.)
  10. Angio Archiv v.9 Biological testing of collagen-impregnated Dacron vascular grafts Chvapil,M.;Moore,W.S.;Noishiki,Y.
  11. J Cardiovasc Surg v.28 A collagen coated vascular prosthesis Scott,S.M.;Gaddy,L.R.;Sahmel,R.;Hoffman,H.
  12. J Vasc Surg v.3 Development of a leak-proff,knitted Dacron vascular prosthesis Quinones-Baldrich,W.J>;Moore,W.S.;Ziomek,S.;Chvapil
  13. Ann Vasc Surg v.5 Experimental and clinical experience with a Gelatin impregnated Dacron prosthesis Drury,J.K.;Schton,T.R.;Cunningham,J.D.;Maini,R.;Pollock,J.G.
  14. Biomaterials v.8 In vitro and in vivo characterization of an impervious polyester arterial prosthesis: the Gelseal triaxial graft Guidoin,R.;Marceau,D.;Rao,T.J.(et al.)
  15. Biomaterials v.10 Experimental evaluation of a gelatin-coated polyester graft used as an arterial substitute Bordenave,L.;Caix,J.;Basse-Cathalinat,B.;Baquey,C.;Midy,D.;Baste,J.C.
  16. ASAIO J v.8 Polyester (Dacron) arterial prostheses treated with cross-linked and freeze-dried albumin Roy,J.;King,M.;Synder,R.(et al.)
  17. Eur Surg Res v.20 Polyester arterial grafis impregnated with cross-linked albumin: the of degradation of the coating in vivo Slimane,S.B.;Guidoin,R.;Mourad,W.;Hebert,J.;King,M.W.;Sigot-Luizard,M.F.
  18. Trans Am Soc Artif Organs v.ⅩⅩⅨ Albumin coated and critical point dried polyster prostheses as substitutes in the thoracic aorta of dogs Guidoin,R.G.;King,M.W.;Awad,J.(et al.)
  19. 의공학회지 v.11 알진이 도포된 인공혈관의 물성 평가 이진호;신병철;강길선;이해방
  20. Br Corros J v.23 Staining procedures for characterizing biofilms in corrosion investigations Chamberlain,A.H.L.;Angela,P.;Campbell,H.S.
  21. New Biologic and Synthetic Vascular Prostheses Biohybrids-biological coatings in synthetic Vascular Prostheses Greisler,H.P.;Greisler,H.P.
  22. Biology of endothelial cells(1st ed.) Endothelial seeding of vascular prostheses Dilley,R.S.;Herring,M.B.;Jaffe,E.A.
  23. Vascular graft update Species selection for vascular graft evaluation Didsheim,P.;Kambic,H.E.;Kantrowitz,A.;Sung,P.
  24. J Biomed Mater Res v.17 Polyester prostheses as substitutes in the thoracic aorta of dogs. I. Evaluation of commercial prostheses Guidoin,R.;Gosselin,C.;Martin,L.;Marois,M.;Laroche,F.