YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

In Vitro Inhibition of Cyclooxygenase by Aspalatone

아스파라톤에 의한 사이클로옥시게나제의 저해 - in Vitro

  • 서대연 (서울대학교 천연물과학연구소) ;
  • 한병훈 (서울대학교 천연물과학연구소)
  • Published : 1995.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

A new antiplatelett agent, aspalatone ([3-(2-methyl-4-pyronyl)]-2-acetyloxybenzoate) was demonstrated to inhibit MDA generation from arachidonic acid catalyzed by partially purified bovine seminal vesicle cyclooxygenase. This inhibition was also observed with acetylsalicylic acid. The results suggest that the mechanism for the antiplatelet effect of aspalatone is, like acetylsalicylic acid, due to its inhibition of cyclooxygenase.

Keywords

References

  1. J. Clin. Invest. v.56 The mechanism of the effect of aspirin on human platelets Roth,G.J.;Majerus,P.W.
  2. J. Phamacol. Exp. Ther. v.248 Differential inhibition by aspirin of platelet thromboxane and renal prostaglandins in the rat Livio,M.;Benigni,A.;Zoja,C.;Begnis,R.;Morelli,C.;Rossini,M.;Garattini,S.;Remuzzi,G.
  3. New Engl. J. Med. v.311 Dose-related kinetics of aspirin: presystemic acetylation of platelet cyclooxygenase Pedersen,A.K.;Fitzgerald,G.A.
  4. TIPS v.10 Aspirin and human platelets: from clinical trials to acetylation of cyclooxygenase and back Patrono,C.
  5. Circulation v.72 Pharmacology of platelet inhibition in humans: implications of the salicylate-aspirin interaction de Gaetano,G.;Cerletti,C.;Dejana,E.;Latini,R.
  6. BMJ v.308 The aspirin papers Underwood,M.J.;More,R.S.
  7. Gastroenterology v.96 Aspirin-induced gastric mucosal injury: Lessons learned from animal models Kauffman,G.
  8. Lancet v.ii Aspirin: a paradoxical effect on bleeding-time(Letter) O'Grady,J.;Moncada,S.
  9. Arzneim. Forsch./Drug Res. v.44 no.Ⅱ Synthesis and antiplatelet effects of the new antithrombotic agent Aspalatone with low ulcerogenicity Han,B.H.;Suh,D.Y.;Yang,H.O.;Park,Y.H.;Kang,Y.H.;Kim,Y.G.
  10. Biochim. Biophys. Acta v.487 Purification and characterization of prostaglandin endoperoxide synthetase from sheep vesicular glands Van der Ouderra, F. A.;Buytenhek,M.;Nugteren,D.H.;Van Drop, D. A.
  11. J. Biol. Chem. v.193 Protein measurement with the folin phenol reagent Lowry,O.H.;Rosebrough,N.J.;Farr,A.L.;Randall,R.J.
  12. Biochem. J. v.239 Purification and characterization of sheep platelet cyclooxygenase. Acetylation by aspirin prevents hemin binding to the enzyme Boopathy,R;Balasubramanian,A.S.
  13. Biochim. Biophys. Acta v.24 A method of estimation of 2-deoxyribose Waravdekar,V.S.;Saslaw,L.D.
  14. Eur. J. Biochem. v.109 Acetylation of prostaglandin endoperoxide synthetase with acetylsalicylic acid Van der Ouderaa, F. J.;Buytenhek,M.;Nugteren,D.H.;Van Dorp, D. A .
  15. Arzneim.-Forsch./Drug Res. v.35 no.Ⅱ Effect of cilostazol on platelet aggregation and experimental thrombosis Kimura,Y.;Tani,T.;Kanbe,T.;Watanabe,K.
  16. J. Clin. Invest. v.61 Inhibition of platelet prostaglandin synthetase by oral aspirin Burch,J.W.;Stanford,N.;Majerus,P.W.
  17. Arzneim. Forsch./Drug Res. Metabolic Fate of the New Antithrombotic Agent Aspalatone in Rats : In Vivo and In Vitro Study Suh,D.Y.;Yang,H.O.;Kim,Y.C.;Han,B.H.