YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effect of Glycyrrhizin on the Differentiation of 3T3-L1 Cell

글리시르히진이 3T3-L1세포의 분화에 미치는 영향

  • Eun, Jae-Soon (Department of Pharmacy, Woosuk University) ;
  • Yum, Jeong-Yul (Department of Pharmacy, Woosuk University) ;
  • Oh, Suk-Heung (Department of Biotechnology, Woosuk University) ;
  • Kweon, Jin (Department of Pharmacy, Woosuk University) ;
  • Kang, Sung-Young (Department of Pharmacy, Woosuk University) ;
  • Oh, Chan-Ho (Department of Biotechnology, Woosuk University) ;
  • So, Joon-No (Department of Biotechnology, Woosuk University) ;
  • Jeon, Hoon (Department of Environmental Engineering, Woosuk University)
  • Published : 1995.10.01
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Abstract

The purpose of this research was to investigate effects of glycyrrhizin on the differentiation of preadipocytes, 3T3-Ll cells and to characterize the action of glycyrrhizin that affect the responses of 3T3-Ll cells during differentiation. The differentiation of 3T3-Ll cells was stimulated by glycyrrhizin, and triglyceride contents was increased in the differentiated 3T3-LI cell extracts. Total protein contents was increased by glycyrrhizin or inductive agents in the differentiated 3T3-Ll cell extracts. Calmodulin contents was increased by inductive agents, but the contents was not affected by glycyrrhizin in the differentiated 3T3-Ll cell extracts. The results suggest that glycyrrhizin has a stimulating activity of adipose conversion, but the activity is not related to calmodulin contents during the process of differentiation of 3T3-LI cells.

Keywords

References

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