YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

General Pharmacology of DWP 401, a Recombinant Human Epidermal Growth Factor

재조합 인간 상피세포 성장인자(DWP 401)의 일반약리작용

  • 천선아 (서울대학교 천연물과학연구소) ;
  • 김상미 (서울대학교 천연물과학연구소) ;
  • 이은방 (서울대학교 천연물과학연구소) ;
  • 임승욱 (대웅제약 중앙연구소) ;
  • 유영효 (대웅제약 중앙연구소) ;
  • 박명환 (대웅제약 중앙연구소)
  • Published : 1995.10.01
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Abstract

The recombinant human epidermal growth factor(DWP 401) was investigated on the pharrnacological actions. DWP 401 had no effects on the hexobarbital-induced sleeping time, locomotor activity, rotarod test, body temperature, analgesic action and anticonvulsant action in mice. It also had no influences on the isolated tracheal muscle and ileum of guinea-pig, isolated uterus and fundus strip of rats. Slight hypotensive action with effect on respiration was revealed at a dose of 8 g/kg i.v. of DWP 401 in rabbits. DWP 401 exhibited a weak inhibitory action of glucose tolerance in normal rats, significantly lowered the blood glucose contents in adrenalectomized rats at .a concentration of 160 g,/kg, and produced a significant inhibitory effect on leucocyte migration in CMC-pouch of rats at a concentration of 32 g/rat. Furthermore, DWP 401 showed a significant decrease on gastric juice volume and acidity. However. DWP 401 had no intestinal propulsion rate and influence on urine excretion.

Keywords

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