Hemostatic Action of Torilis fructus

사상자 물추출물의 혈액 응고 작용

  • 김환수 (선경인더스트리 생명과학연구소) ;
  • 박병욱 (선경인더스트리 생명과학연구소) ;
  • 김기협 (선경인더스트리 생명과학연구소) ;
  • 박광식 (선경인더스트리 생명과학연구소)
  • Published : 1995.02.01

Abstract

The acetone precipitates of the hot water extract of Torilis ftuctus showed strong hemostatic activity which was not inhibited by aspirin. This activity was not through platelet activation but possibly through activating some coagulation factors in plasma. The hemostatic action of the precipitates was not active by oral adminitration and no behavioral toxicity was appeared in treated mice. However, mice treated with the acetone precipitates through tail vein showed serious tremor and then were killed probably by the thrombus produced in the body. The hemostatic activity was still remained after treatment with $\beta$-glucosidase, $\beta$-alactosidase, $\alpha$-amylase, subtilisin BPN', or trypsin but completely lost by acid hydrolysis. The active components seemed to be a complex of unidentified macromolecules to which some phenolic compounds were strongly bound.

Keywords

References

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