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The Pharmaceutical Society of Korea (대한약학회)
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Effects of Ethylcholine Aziridinium, Scopolamine and Mor-phine on Learning Behaviors in Morris Sater Maze.

  • Lim, Dong-Koo (College of Pharmacy, Chonnam National University) ;
  • Wee, Sun-Mee (College of Pharmacy, Chonnam National University) ;
  • Ma, Young (College of Pharmacy, Chonnam National University) ;
  • Yi, Eunyoung (College of Pharmacy, Chonnam National University)
  • Published : 1995.10.01
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Abstract

To assess the behavior of the various chemicals, such as ethylcholine axiridinium (AF54A), scopolamine and morphine, the chemicals were administered into eitheer rat or mice. And water maze tests were performed before and during drug administration. In AF64A-treated groups (3 nmol/each ventricle), the latencies to escape was significantly increased in both of the pretraining-and posttraining groups. In scopolamine-treatment (2mg/kg, sc) to the pretrained group, the latency to escape was significantly shortened after the acute administration of scopolamine. However in subscute treatment group with scopolamine, the latency to escape was significantly increased. In morphine-treated groups (10 mg/kg, ip), the subacute treatmment with morphine, the latency to escape was not ahcnged. The results indicate that each chemical induces the learning impariment. However the chrmical-induced learning impairment may have different characteristics upon the exposed chemical. Also the results suggest that both the motivation and the retrieval of memory might be impaired by AF64A.

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References

  1. Behav. Neural Biol. v.45 Effects of intrahippocampal injections of the cholinergic neurotoxin AF64A on open-field activity and avoidance learning in the rat Bailey,E.;Overstreet,D.;Crocker,A.
  2. Science v.217 The cholinergic hypothesis of geriatric memory function Bartus,R.T.;Dean,R.L.;Beer,B.;Lippa,A.S.
  3. Parkinson's and Alzheimer's disease: Strategies for Research and development AF64A induced cholinotoxicity: behavioral and biochemical correlates Brandeis,R.;Pittel,Z.;Lachmam,C.;Heldman,E.;Luz,S.;Dachir,S.;Levy,A.;Hanin,I.;A.Fisher(Ed.);I.I.Hanin(Ed.);C.Lachman(Ed.)
  4. Behav. Neurosci. v.100 Differential effects of cholinergic blockade on performance of rats in the water tank navigation task and in a radial arm maze Buresova,O.;Bolthius,J.;Bures,J.
  5. Brain Res. v.463 AF64A induced working memory impairment: behavioral, neurochemical and histological correlates Chrobak,J.J.;Hanin,I.;Schmechel,D.E.;Walsh,T.J.
  6. Brain Res. v.504 Gemicholinum-3 prevents the working memory impairments and the cholinergic hypofunction induced by ethycholine aziridinium ion (AF64A) Chrobak,J.J.;Spates,M.J.;Stackman,R.W.;Walsh,T.J.
  7. Trend in Pharmacol. v.5 Anatomy of cholinergic projections to cerebral cortex: implications for the pathophysiology of senile dementia of the Alzheimer's type Coyle,J.T.;Price,D.;DeLong,M.
  8. Neurochem. Res. v.9 Brain acetylcholine during morphine withdrawal Crossland,J.;Ahmed,K.Z.
  9. Behav. Neural Biol. v.45 Scopolamine effects on memory retention in mice: a model of dementia? Flood,J.;Cherkin,A.
  10. Life Sci. v.23 Manipulation of opiate activity in the amygdala alters memory processes Gallagher,M.;Kapp,B.S.
  11. Psychopharmacology v.66 Effect of naloxone and morphine on various forms of memory in the rat: Possible role of endogenous opiate mechanisms in memory consolidation Izquierdo,I.
  12. Peptides v.1 Memory, opiate receptors, and aging Jensen,R.A.;Messing,R.B.;Spiehler,V.R.;Martinez,J.L.;Vasquez,B.J.;McGaugh,J.L.
  13. Jpn. J. Psychopharmacol. v.10 Modulation of brain function by opioids: With special reference to learning and memory process Kaneto,H.
  14. Neuropharmacology v.26 Time course of ethylcholine aziridinium ion (AF64A)-induced cholinotoxicity in vivo Leventer,S.M.;Wulfert,E.;Hanin,I.
  15. Pharmacol. Biochem. Behav. v.18 Chronic administration of cholinergic agents: effects on behavior and calmodulin Loullis,C.;Dean,R.;Lippa,A.;Meyerson,L.;Beer,B.;Bartus,R.
  16. J. Neurochem. v.41 Selective presynaptic cholinergic neurotoxicity following intrahippocampal AF64A injection in rats Mantione,C.R.;Zigmond,M.J.;Fisher,A.;Hanin,I.
  17. Science v.228 Loss of M₂ muscarinic receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation Mash,D.C.;Flynn,D.D.;Potter,L.T.
  18. Psychopharmacology v.63 Facilitation of memory processing by post-trial morphine: Possible involvement of reinforcement mechanisms? Mondadori,C.;Waser,P.G.
  19. Learn Mot. v.12 Spatial localization does not require the presence of local cues Morris,R.G.M.
  20. Jpn. J. Pharmacol. v.48 Effects of intracerebroventricular injection of AF64A on learning behaviors in rats Nakahara,N.;Igo,Y.;Mizobe,F.;Kawanishi,G.
  21. Psychopharmacology v.100 State dependent and/or memory retrieval by morphine in mice Nishimura,M.;Shiigi,Y.;Kaneto,H.
  22. The brain in stereotaxic coordinates Paxinos,G.;Watson,C.
  23. Eur. J. Pharmacol. v.74 Adaptation of presynaptic acetylcholine autoreceptors following long-term drug treatment Raiterri,M.;Marchi,M.;Paudice,P.
  24. Neurosci. v.47 Alzheimer's disease: Is the decrease of the cholinergic innervation of the hippocampus related to intrinsic hippocampal patholigy? Ransmayr,G.;Cervera,P.;Hirsch,E.C.;Fisher,W.;Agid,Y.
  25. J. Neurochem. v.40 Presynaptic cholinergic dysfunction in patients with dementia Sims,N.R.;Bowen,D.M.;Allen,S.J.;Smith,C.C.T.;Neary,D.;Thomas,D.J.;Davison,A.N.
  26. Drug Dev. Res. v.3 Effects of anticholinergic drugs on learning and memory Spencer,D.G.Jr.;Lal,H.
  27. Behav. Neurosci. v.99 Central cholinergic involvement in working memory: Effects of scopolamine on continuous nonmatching and discrimination performance in the rat Spencer,D.G.Jr.;Pontecorvo,M.J.;Heise,G.A.
  28. Ann. Rev. Pharmacol. Toxicol. v.21 Presynaptic receptors Starke,K.
  29. Yakugaku Zassi v.112 Strain differences of mices in learning of swimming behavior and effect of hemicholinium and vasopressin. Observation by a simple water maze appratus Yamada,K.;Statoh,M.;Tokoi,J.;Tsuboi,M.;Nagasaka,T.