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The Pharmaceutical Society of Korea (대한약학회)
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Anti-hepatotoxic Activity of Icariside II, a Constituent of Epimedium koreanum

  • Cho, Nam-Jin (College of Pharmacy, Seoul National University) ;
  • Sung, Sang-Hyun (College of Pharmacy, Seoul National University) ;
  • Lee, Heum-Sook (Department of Food Science & Technology, Seoul National Polytechnic University) ;
  • Jeon, Mee-Hee (Korea and Ministry of Health and Welfare, Central Pharmaceutical Affairs Council) ;
  • Kim, Young-Choong (College of Pharmacy, Seoul National University)
  • Published : 1995.08.01
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Abstract

Icariside II, a flavonol glycoside, was isolated from the aerial part of Epimedium Koreanum Nakai by the anti-hepatotoxic acitivity guided fractionation technique employing $CCl_4-in-toxicated$ primary cultured rat hepatocytes as an assay system. Its anti-hepatotoxic activity was evaluated by measuring activity of glutamic pyruvic transaminase released from the $CCl_4-in-toxicated$ primary cultured rat hapatocytes. Icariside II significantly reduced the activity of glutamic pyruvic transaminase released from the $CCl_4-in-toxicated$ primary cultured rat hepatocytes and resulted in 78% recovery of the toxicity at the concentration of $200{\;}\mu\textrm{m}$. The anti-hepatotoxic activity of icariside II on the $CCl_4-in-toxicated$ primary cultured rat hepatocytes was as potent as that of silybin.

Keywords

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