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The Pharmaceutical Society of Korea (대한약학회)
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Synthesis of 4-Hydroxycoumarion Derivatives-1: An Efficient Synthesis of Flocoumafen

  • Park, Oee-Sook (Department of Chemistry, Chungbuk National University) ;
  • Jang, Bong-Suek (Department of Chemistry, Chungbuk National University)
  • Published : 1995.08.01
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Abstract

An anticoagulant, 4-hydroxy-3-[1, 2, 3, 4-tetrahydro-3-[4-(4-trifluoromethylbenzyloxy)phenyll-1 -naphthyl]coumarin (Flocoumafen) was synthesized in 8 steps starting from phenylacetyl shloride and anisole. The key step in the synthesis involves the reaction of 3-(4-methoxyphenyl)-1-teralol with 4-hydroxycoumarin to give 4-hydroxy-3 [1, 2, 3, 4-tetrahydro-3-[4-emthoxyphenyl]-1-naphthyl]coumarin.

Keywords

References

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