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The Pharmaceutical Society of Korea (대한약학회)
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Effects of Chronic Dextromethorphan Administration on the Cellular Immune Responses in Mice

  • Kim, Hyoung-Chun (College of Pharmacy, Kangwon National University) ;
  • Jhoo, Wang-Kee (College of Pharmacy, Kangwon National University) ;
  • Kwan, Myung-Sang (College of Animal Agriculture, Kangwon National University) ;
  • Hong, Jau-Shyong (Laboratory of Environmental Neuroscience, National Institute of Environment Health Science, Nationl Institute of Health)
  • Published : 1995.08.01
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Abstract

We examined the chronic effect of dextromethorphan(DM) on the cellular immune responses in mice. T cell simulator, phytohemagglutinin did not show singificant effect on lymphocyte proliferation. Costimulator of T and B cell, pokeweed mitogen, and B cell stimulator, lipopolysaccharide exhibited DM-induced decreased lymphocyte proliferation. Singificantly suppressed natural killer (NR) cell cytotoxicity was evidenced following 6 months DM exposure. These results suggest that chronic DM administration pertub B cell functioning and NK cell cytotoxicity. In addition, prenatal DM exposure did not potentiate the immunomodulation in postnatal effect induced by chronic DM.

Keywords

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