BMB Reports
- Volume 28 Issue 1
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- Pages.79-82
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- 1995
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- 1976-670X(eISSN)
An Additional Mechanism for the Cytotoxicity of 2-Chloroethylethyl Sulfide in Spleen Lymphocytes; Lysosomal Labilization
- Choi, Dae-Sung (Advanced Technology Research Center (#6-7), Agency for Defense Development) ;
- Shin, Sung-Ho (Advanced Technology Research Center (#6-7), Agency for Defense Development) ;
- Kim, Yun-Bae (Advanced Technology Research Center (#6-7), Agency for Defense Development) ;
- Cha, Seung-Hee (Advanced Technology Research Center (#6-7), Agency for Defense Development) ;
- Sok, Dai-Eun (Advanced Technology Research Center (#6-7), Agency for Defense Development)
- Published : 1995.01.31
Abstract
Exposure of spleen lymphocytes to 2-chloroethylethyl sulfide (CEES) leads to a reduction of the intracellular ATP level, followed by a decrease in cell viability. Addition of nicotinamide, an inhibitor of poly(ADP-ribose) polymerase (PADPRP), restores both ATP level and viability, indicating that an activation of PADPRP is responsible for the cytotoxicity of CEES. The involvement of a