Antihyperlipedimic activity of several traditional herbal medicines on experimental hyperlipidemia in rats

고지혈증 랫트를 이용한 수종 전통 한약제의 항고지혈 효과(II)

Hyperlipidemia is a major predisposing factor of atherosclerosis and cerebrovascular accidents. In effort to develope a hypolipidemic drug from medicinal herb, We tested three prescriptions of traditional medicine for the lipid lowering effect on diet-induced hyperlipidemic rats. GyejI-Bokryung-Hwan, Ohyak-Sunki-San, and Shihoga-Yongol-Moryu-Tang were selected based on the comnon prescriptions for patients with hyperlipidemia-related diseases. Water extract from each prescriptions was made by the method used in the clinical setting, and administered intragastrically once a day, for 4 weeks. Fenofibrate and lovastatin were given by the same method as the control drugs. Blood levels of total cholesterol(TC), high density lipoprotein(HDL), low density lipoprotein (LDL), and triglyceride(TG) were measured before, 1, 2, 3, and 4 weeks after starting the drug administration. All of the traditional prescriptions did not show lipid lowering effect, while fenofibrate lower the blood cholesterol levels(TC;from 215mg/dl before to 182m41 at 4 weeks-point of drug administration, and LDL ;from 203mg/dl before to aut 161, and 163mg/dl at 3 and 4 week-point respectively). Oyak-Sunki-San increased the level of TC (from 283mg/dl to over 350mg/dl starting from the first week of drug administratin). Effects on TG variable in the cases of traditional medicines and control drug In conclusion, any of the three traditional medical prescriptions did not decrease the level of blood cholesterol.