Applied Biological Chemistry
- 제38권5호
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- Pages.468-472
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- 1995
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- 2468-0834(pISSN)
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- 2468-0842(eISSN)
Aflatoxin $B_1\;(AFB_1)$ 과 2-amino-3-methylimidazo[4,5-f]quinoline (IQ)에 대한 caryophyllene oxide의 항돌연변이성
Potent Antimutagenic Activity of Caryophyllene Oxide for Aflatoxin $B_1\;(AFB_1)$ and 2-Amino-3-Methyl-imidazo[4,5-f]Quinoline (IQ)
- 이정민 (경상대학교 농과대학 농화학과, 암연구소, 식물분자생물학 우수연구소) ;
- 이은주 (경상대학교 농과대학 농화학과, 암연구소, 식물분자생물학 우수연구소) ;
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반경녀
(경상대학교 농과대학 농화학과, 암연구소, 식물분자생물학 우수연구소) ;
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김정옥
(부산여자대학교 자연과학대학 화학과) ;
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하영래
(경상대학교 농과대학 농화학과, 암연구소, 식물분자생물학 우수연구소)
- Lee, Jung-M. (Department of Agricutural Chemistry, Gyeongsang Institute for Cancer Research, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University) ;
- Lee, Eun-J. (Department of Agricutural Chemistry, Gyeongsang Institute for Cancer Research, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University) ;
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Bahn, Kyeong-N.
(Department of Agricutural Chemistry, Gyeongsang Institute for Cancer Research, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University) ;
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Kim, Jeong-O.
(Department of Chemistry, Pusan Women's University) ;
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Ha, Yeong-L.
(Department of Agricutural Chemistry, Gyeongsang Institute for Cancer Research, Plant Molecular Biology and Biotechnology Research Center, Gyeongsang National University)
- 발행 : 1995.10.31
초록
Caryophyllene oxide (CPO)는 전통생약제나 향신료의 essential oil에 상당량 함유되어 있다. Caryophyllene (CP)의 산화반응이나 효소반응에 의해 생성되어 주로 flavor component로 이용되는 CPO는 강력한 생리활성을 가진다. 따라서 본 연구에서는 CPO의 항돌연변이성을 Ames의 preincubation 법으로 조사하였다. S-9 fraction은 Arochor 1254를 몸무게 kg당 500mg을 투여한 Sprague-Dawley rat의 간으로부터 조제하였고 aflatoxin
Substantial amount of caryophyllene oxide (CPO) is present in the essential oils of traditionally-used folk medicinal plants and herbal spices. The CPO, produced via chemical and/or enzymatic reaction of caryophyllene (CP), has largely being used as a flavoring component and exhibited a variety of biological activities. Now, we report the antimutagenic activity of CPO determined by Ames's preincubation test. S-9 fraction was prepared from the liver of rats treated with Arochor 1254. Anatoxin
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