Journal of Pharmaceutical Investigation
- Volume 25 Issue 4
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- Pages.353-363
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- 1995
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Effect of Ion-Pair on Jejunal and Nasal Absorption of Cefotaxime
세포탁심의 공장 및 비점막흡수에 미치는 이온쌍의 효과
- Park, Gee-Bae (College of Pharmacy, Chung-Ang University) ;
- Jeon, Seung (R&D CENTER, HANDOK PHARMACEUTICAL CO., LTD.) ;
- Lee, Kwang-Pyo (College of Pharmacy, Chung-Ang University)
- Published : 1995.12.20
Abstract
The purpose of this study was to investigate the intestinal and nasal absorption enhancement of cefotaxime (CTX) by ion-pairing with counterions and to design an effective oral and intranasal drug delivery system for antibiotics. Counterions for absorption promotion were cationic surfactants [cetylpyridinium chloride (CP), cetrimide (CT) and benzalkonium chloride (BA)]. In the presence of counterions, the apparent partition coefficient of cefotaxime was increased depending on the molar concentration of the counterions. Anion interference was observed for ion-pairing of cefotaxime with counterions because of the counterbalance between an anion and counterions. The present study employed the in situ simultaneous nasal and intestinal perfusion technique in rats. The apparent permeabilities