생약학회지 (Korean Journal of Pharmacognosy)

  • 제26권4호
  • /
  • Pages.344-348
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  • 1995
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  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

약용식물 오수유로부터 다제약제 내성 조절물질의 분리

Isolation of Modulators for Multidrug Resistance from the Fruits of Evodia officinalis

  • Lee, Sung-Woo (College of Pharmacy, Chungbuk National University) ;
  • Hwang, Bang-Yeon (College of Pharmacy, Chungbuk National University) ;
  • Kim, Se-Eun (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Kim, Hwan-Mook (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Kim, Young-Ho (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Lee, Kyong-Soon (College of Pharmacy, Chungbuk National University) ;
  • Lee, Jung-Joon (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
  • Ro, Jai-Seup (College of Pharmacy, Chungbuk National University)
  • 발행 : 1995.12.30
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초록

Preliminary screening test of modulators for multidrug resistance with 400 medicinal plants was carried out by using human multidrug resistance cell line, KB-V1. Among active medicinal plants, the unripe fruits of Evodia officinalis showed a potent modulating activity of MDR. From MeOH extract of this plant, we isolated two indole alkaloids, rutaecarpine (1) and evodiamine (2), by repeated silicagel column chromatography. Rutaecarpine increased the cytotoxicities of vinblastine and taxol against multidrug resistance cells, but evodiamine showed no modulating activity in spite of its potent cytotoxic activities.

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