Korean Journal of Pharmacognosy (생약학회지)
- Volume 26 Issue 4
- /
- Pages.344-348
- /
- 1995
- /
- 0253-3073(pISSN)
- /
- 2288-9299(eISSN)
Isolation of Modulators for Multidrug Resistance from the Fruits of Evodia officinalis
약용식물 오수유로부터 다제약제 내성 조절물질의 분리
- Lee, Sung-Woo (College of Pharmacy, Chungbuk National University) ;
-
Hwang, Bang-Yeon
(College of Pharmacy, Chungbuk National University)
;
- Kim, Se-Eun (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
-
Kim, Hwan-Mook
(Korea Research Institute of Bioscience and Biotechnology, KIST)
;
-
Kim, Young-Ho
(Korea Research Institute of Bioscience and Biotechnology, KIST)
;
-
Lee, Kyong-Soon
(College of Pharmacy, Chungbuk National University)
;
- Lee, Jung-Joon (Korea Research Institute of Bioscience and Biotechnology, KIST) ;
-
Ro, Jai-Seup
(College of Pharmacy, Chungbuk National University)
- 이성우 (충북대학교 약학대학) ;
-
황방연
(충북대학교 약학대학)
;
- 김세은 (KIST 생명공학연구소) ;
-
김환묵
(KIST 생명공학연구소)
;
-
김영호
(KIST 생명공학연구소)
;
-
이경순
(충북대학교 약학대학)
;
- 이정준 (KIST 생명공학연구소) ;
-
노재섭
(충북대학교 약학대학)
- Published : 1995.12.30
Abstract
Preliminary screening test of modulators for multidrug resistance with 400 medicinal plants was carried out by using human multidrug resistance cell line, KB-V1. Among active medicinal plants, the unripe fruits of Evodia officinalis showed a potent modulating activity of MDR. From MeOH extract of this plant, we isolated two indole alkaloids, rutaecarpine (1) and evodiamine (2), by repeated silicagel column chromatography. Rutaecarpine increased the cytotoxicities of vinblastine and taxol against multidrug resistance cells, but evodiamine showed no modulating activity in spite of its potent cytotoxic activities.