Korean Journal of Pharmacognosy (생약학회지)

The Korean Society of Pharmacognosy (한국생약학회)
권호 표지

Inhibitory Effects of Extracts from Traditional Herbal Drugs on 5-Hydroxytryptophan-Induced Diarrhea in Mice

생쥐에서 5-Hydroxytryptophan에 의한 설사에 대한 각종 전통 생약 추출물의 억제 효과

  • Yoo, Jae-Sun (Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University) ;
  • Jung, Jun-Sub (Sam-Chun-Dang Pharm. Co. Research Institute) ;
  • Lee, Tae-Hee (Oriental Medicine College, Kyungwon University) ;
  • Son, Kun-Ho (Department of Food and Nutrition, Andong National University) ;
  • Suh, Hong-Won (Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University) ;
  • Song, Dong-Keun (Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University) ;
  • Kim, Yung-Hi (Department of Pharmacology, College of Medicine, Institute of Natural Medicine, Hallym University)
  • 유재선 (한림대학교 의과대학 약리학교실, 천연의약연구소) ;
  • 정전섭 (삼천당제약 중앙연구소) ;
  • 이태희 (경원대학교 한의과대학) ;
  • 손건호 (안동대학교 식품영양학과) ;
  • 서홍원 (한림대학교 의과대학 약리학교실, 천연의약연구소) ;
  • 송동근 (한림대학교 의과대학 약리학교실, 천연의약연구소) ;
  • 김영희 (한림대학교 의과대학 약리학교실, 천연의약연구소)
  • Published : 1995.12.30
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Abstract

To find serotonin(5-hydroxytryptamine, 5-HT)-antagonizing activities in traditional herbal drugs, crude extracts from 66 kinds of traditional herbal drugs were randomly screened for inhibitory effects on 5-hydroxytryptophan(HTP)-induced diarrhea in mice. Intraperitoneal injection of 5-HTP(2.5 mg/kg) induced diarrhea in 92% of mice, when observed from 10 to 15 min after injection. Crude extracts(2 g/kg) from 66 kinds of traditional herbal drugs were orally pretreated for 1 h before 5-HTP injection. Of the 66 herbal drugs screened, Ephedrae Herba(麻黃), Cimicifugae Rhizoma(升麻), Anisi stellati Fructus(八角茴香), Aurantii Fructus(枳實), Polygalae Radix(遠志) showed the most potent inhibiting activities against 5-HTP(2.5 mg/kg)-induced diarrhea in mice. There are at least 3 possible mechanisms that would be responsible for the inhibitory effect of crude extracts on 5-HTP-induced diarrhea; 1) crude extract-induced inhibition of the activity of aromatic aminoacid decarboxylase catalyzing the conversion of 5-HTP to 5-HT, 2) crude extract-induced blockade of 5-HT receptor(s) in the gastrointestinal tract responsible for 5-HTP-induced diarrhea, 3) crude extract-induced inhibition of gastrointestinal activity, irrespective of 5-HT system. The exact mechanisms and molecules, responsible for the inhibitory effect of crude extracts on 5-HTP-induced diarrhea remain to be clarified.

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