Korean Journal of Pharmacognosy (생약학회지)
- Volume 26 Issue 3
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- Pages.253-258
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- 1995
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- 0253-3073(pISSN)
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- 2288-9299(eISSN)
Cytotoxicity of Petroleum Ether Extract of Euonymus alatus
귀전우 Petroleum Ether 추출물의 세포독성
-
Eun, Jae-Soon
(Department of Pharmacy, Woosuk University) ;
- Park, Sang-Ho (Department of Pharmacy, Woosuk University) ;
- Kweon, Jin (Department of Pharmacy, Woosuk University) ;
- Kim, Young-Ahn (Department of Pharmacy, Woosuk University) ;
- Kang, Sung-Young (Department of Pharmacy, Woosuk University) ;
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Oh, Chan-Ho
(Department of biotechnology, Woosuk University) ;
- Jeon, Hoon (Department of Environmental Engineering, Woosuk University)
-
은재순
(우석대학교 약학과) ;
- 박상호 (우석대학교 약학과) ;
- 권진 (우석대학교 약학과) ;
- 김영안 (우석대학교 약학과) ;
- 강성룡 (우석대학교 약학과) ;
-
오찬호
(우석대학교 생물공학과) ;
- 전훈 (우석대학교 환경공학과)
- Published : 1995.09.30
Abstract
The purpose of this research was to investigate the effects of petroleum ether extract of Euonymus alatus (EAP) on the proliferation of human tumor cells. EAP inhibited the proliferation of HeLa, Hep G2, KHOS/NP and A431 cells. The cytotoxicity of doxorubicin on human tumor cells and Balb/c 3T3 cells were increased by the combination of EAP. EAP did not affect the proliferation of Balb/c 3T3 cells, mouse spleen cells and human lymphocytes. These results suggest that EAP has the cytotoxicity on human tumor cells without cytotoxicity on Balb/c 3T3 cells, mouse spleen cells and human lymphocytes, and increase the cytotoxicity of doxorubicin.
Keywords
- Euonymi lignum suberatum;
- mouse spleen cells;
- human tumor cells Balb/c 3T3;
- human lymphocyte;
- MTT assay;
- cytotoxicity