Natural Product Sciences

  • 제1권1호
  • /
  • Pages.1-4
  • /
  • 1995
  • /
  • 1226-3907(pISSN)
  • /
  • 2288-9027(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

Isolation of Cytotoxic Compounds from the Leaves of Xanthium strumarium L.

  • Ahn, Jong-Woong (Natural Products Laboratory, Korea Research Institute of Chemical Technology) ;
  • No, Zae-Sung (Natural Products Laboratory, Korea Research Institute of Chemical Technology) ;
  • Ryu, Shi-Yong (Natural Products Laboratory, Korea Research Institute of Chemical Technology) ;
  • Zee, Ok-Pyo (College of Pharmacy, Sungkyunkwan University) ;
  • Kim, Seong-Kie (Natural Products Laboratory, Korea Research Institute of Chemical Technology)
  • 발행 : 1995.12.01
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초록

MeOH extract of the leaves of Xanthium strumarium L. were found to have cytotoxic activities against five human tumor cell lines. Cytotoxicity-guided chromatographic fractionation led to the isolation of the ${\alpha}-methylene$ containing sesquiterpenes, xanthatin, 8-epi-xanthatin and 8-epi-tomentosin. 8-epi-Xanthatin was found to be far more cytotoxic than 8-epi-tomentosin, which lacks the conjugated enone moiety present in 8-epi-xanthatin.

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