The Korean Journal of Pharmacology (대한약리학회지)
- Volume 31 Issue 2
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- Pages.153-164
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- 1995
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- 0377-9459(pISSN)
Effect of Ephedrine on the Levels of Biogenic Amines and Their Metabolites in Rat Brain
Ephedrine이 뇌내 Biogenic Amine 함량에 미치는 영향
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Lee, Kyung-Eun
(Department of Pharmacology, Ewha Womans University College of Medicine)
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이경은
(이화여자대학교 의과대학 약리학교실)
- Published : 1995.09.30
Abstract
Sympathomimetic amines, especially ephedrine, are a major ingredient in proprietary medications for symptomatic treatment of upper respiratory infections. Their frequent uses can lead to occasional instances of abuse and habituation. The clinical symptoms of ephedrine abuse are similar to that of amphetamine psychosis and resemble closely that of schizophrenia. Because both amphetamine psychosis and schizophrenia are thought to be mediated primarily through the action on catecholamines, ephedrine-induced changes of the biogenic amines can be suspected. However, there were few studies about the central effects of ephedrine because of the milder central action than peripheral. Therefore, the present investigation was undertaken to elucidate the relations between the effects of single or repeated administration of ephedrine on the regional levels of biogenic amines in rat brain and ephedrine-induced CNS stimulation. The male Sprague-Dawley rats weighing