The Korean Journal of Physiology
- Volume 29 Issue 2
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- Pages.225-232
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- 1995
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- 0300-4015(pISSN)
Phorbol Ester-Induced Periodic Contraction in Isolated Rabbit Jugular Vein
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Ryu, Jae-Cheol
(Department of Physiology, College of Medicine, Pusan National University) ;
- Jung, Dong-Keun (Department of Physiology, College of Medicine, Pusan National University) ;
- Lee, Sang-Ho (Department of Physiology, College of Medicine, Pusan National University)
- Published : 1995.12.30
Abstract
The present study was conducted to evaluate the effect of phorbol 12,13-dibutyrate (PDBu) on the contraction of rabbit jugular vein in vitro. PDBu concentrations of greater than 10 nM induced a periodic contraction which was composed of rapid contraction, plateau and slow relaxation. The frequency of periodic contraction increased as PDBu concentration increased. The PDBu-induced contraction was inhibited by staurosporine (100 nM), it was not changed by tetrodotoxin