The Korean Journal of Physiology
- Volume 29 Issue 1
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- Pages.103-111
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- 1995
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- 0300-4015(pISSN)
Induction of Oscillatory Firing Activity by TTX in Rat Cerebellar Purkinje Cells
- Seo, Wha-Sook (Inha University, Department of Nursing, College of Medicine)
- Published : 1995.06.30
Abstract
Intracellular recordings were obtained from Purkinje cells in rat cerebellar slices maintained in vitro. Adding tetrodotoxin to the superfusion solution produced a typical pattern of repetitive burst firing consisting of a cluster of action potentials followed by a long hyperpolarization. TTX-induced oscillatory activity was not due to modulation of membrane potential although underlying mechanisms for maintenance of oscillatory activity were influenced by membrane voltage. The mechanism of TTX-induced oscillation was not related to the presence or amplitude of