대한약리학회지 (The Korean Journal of Pharmacology)
- 제31권1호
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- Pages.27-37
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- 1995
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- 0377-9459(pISSN)
뇌혈류 자가조절에 대한 Endothelium-derived Relaxing Factor의 역할
Role of Endothelium-derived Relaxing Factor in Cerebral Autoregulation in vivo
-
Hong Ki-Whan
(Department of Pharmacology, College of Medicine, Pusan National University, Center for Biofunctional Molecules, Pohang) ;
- Yu Sung-Suk (Department of Pharmacology, College of Medicine, Pusan National University) ;
-
Rhim Byung-Yong
(Department of Pharmacology, College of Medicine, Pusan National University)
- 발행 : 1995.06.01
초록
본 연구에서는 콜린성 기전에 반응하여 분비되는 내피 의존성 이완물질(endothelium-derived relaxing factor, EDRF)나 nitric oxide(NO)가 마취 흰쥐의 뇌혈류 자가조절기전에 관여할 가능성을 관찰하였다. Acetylcholine(
In anesthetized rats, we examined the possibility that endothelium-derived relaxing factor (EDRF) or nitric oxide (NO) released in response to cholinergic mechanism may contribute to the reflex autoregulation of cerebral blood flow. Suffusion with mock cerebrospinal fluid (CSF), containing acetylcholine (ACh,
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