생물정신의학 (Korean Journal of Biological Psychiatry)
- 제1권1호
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- Pages.117-123
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- 1994
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
정신분열증에서의 연성 신경학적 증상과 항정신병 약물 치료의 관련성
Relationship Between Neurologic Soft Signs and Neuroleptic Treatment in Patients with Schizophrenia
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채정호
(계요병원 및 한국신경정신의학 연구소) ;
- 정찬호 (계요병원 및 한국신경정신의학 연구소) ;
- 함웅 (계요병원 및 한국신경정신의학 연구소) ;
- 이규항 (계요병원 및 한국신경정신의학 연구소) ;
- 이정균 (계요병원 및 한국신경정신의학 연구소)
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Chae, Jeong-Ho
(keyo Hospital and Korean Neuropsychiatric Research Institute) ;
- Chung, Chan-Ho (keyo Hospital and Korean Neuropsychiatric Research Institute) ;
- Hahm, Woong (keyo Hospital and Korean Neuropsychiatric Research Institute) ;
- Lee, Kyu-Hang (keyo Hospital and Korean Neuropsychiatric Research Institute) ;
- Lee, Chung-Kyoon (keyo Hospital and Korean Neuropsychiatric Research Institute)
- 발행 : 1994.12.25
초록
정신분열증 환자에서 연성 신경학적 증상이 많이 나타나는 것은 많은 연구에서 확인된 바 있으나 이것이 항정신병 약물 복용 등에 의하여 발생하는 부수적인 현상일 가능성이 배제되지 않고 있다. 본 연구는 항정신병 약물 복용군과 비복용군간의 연성 신경학적 증상 발현의 차이를 알아보고자 시도되었다. 항정신병 약물을 전혀 복용하지 않은 28명과 현재 항정신병 약물로 치료 중에 있는 31명의 정신분열증 환자에서 연성 신경학적 증상을 구조화된 평가척도인 한국어판 신경학적 평가척도로 조사하였고 약물용량과 투여기간 및 부작용과의 관계도 알아보았다. 항정신병 약물 비복용군의 신경학적 평가척도의 총점은
This study was performed to examine the role of neuroleptics may in the development of neurologic soft signs in patients with schizophrenia. Neurologic soft signs were evaluated in 28 neuroleptic naive patients with schizophrenia or schizophreniform disorder and 31 neuroleptic non-naive patients with schizophrenia using a structured tool for measuring neurologic abnormalities, Neurological Evaluation Scale-Korean version(NES-K). Relationship to dose, duration and neurological side effects of neuroleptic treatment were also evaluated. Total scores of NES-K in neuroleptic naive group were significantly higher than those of non-naive group. Scores of motor coordination, sequencing of complex motor acts and others items in functional subcategories were also significantly higher in drug-naive patients. The sensory integration item was not different between two groups. After controlling covariates such ac dose of neuroleptics, age and sex, total scores, motor coordination and others items of NES-K were significantly higher in neuroleptic naive group. However there was no difference between drug naive and non-naive group in the sequencing of complex motor acts item due to effects of these covariates. In neuroleptic non-naive group the dosage of neuroleptics correlated with the motor coordination item, nor were there relationships between duration and side effects of neuroleptic treatment and neurologic soft signs. These findings suggest that neuroleptic treatment may play a only relative role in the development of neurologic soft signs in patients with schizophrenia and these abnormalities may be one of possible trait markers of schizophrenia. To elucidate this opinion, well-controlled, prospective study in same subjects will be helpful.