Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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A Linkage Study of Chromosome 5 D5S39(p105-153Ra), D5S76(p105-599Ha), and $D_2$, $D_3$ Receptor Gene($DRD_2$, $DRD_3$) in Schizophrenics in Korean Pedigree

한국인 정신분열병 가계의 염색체 5번 D5S39(p105-153Ra), D5S76(p105-599Ha) 및 도파민 $D_2$, $D_3$ 수용체 유전자좌간의 연관관계 연구

  • Oh, Kang-Seob (Department of Neuropsychiatry, Koryo General Hospital) ;
  • Kim, Young-Tae (Department of OB/GY, Korea University College of Medicine) ;
  • Lee, Min-Soo (Department of Neuropsychiatry, Korea University College of Medicine)
  • 오강섭 (고려병원 신경정신과) ;
  • 김영태 (고려대학교 의과대학 산부인과학교실) ;
  • 이민수 (고려대학교 의과대학 신경정신과학교실)
  • Published : 1994.12.25
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Abstract

The author examined the relationship of two markers, D5S39(p105-153Ra), D5S76(p105-599Ha) of chromosome 5 and $D_2$, $D_3$ receptor genes in a Korean schizophrenic pedigree using polymerase chain reaction(PCR). The results were as follows : 1) On D5S39 locus, 5 different alleles(224/226 bp : 4 cases, 218/226 bp : 3 cases, 222/226 bp : 3 cases, 218/230 bp : 1 case, 222/224 bp : 1 case) were produced. 2) On D5S76 locus, 5 different alleles(102/112 bp : 4 cases, 94/112 bp : 3 cases, 108/112 bp 3 cases, 94/94 bp : 1 case, 102/108 bp 1 case) were produced. 3) On $D_2$ receptor gene, 3 different alleles($A_1A_2$ : 8 cases, $A_1A_1$ : 2 cases, $A_2A_2$ : cases) were produced. 4) On $D_3$ receptor gene, 2 different alleles(1/2 : 7 cases, 1/1 : 5 cases) were produced. The author had not find any specific alleles on all four loci in all pedigree nor any specific alleles in the schizophrenic patients. Though the author has not found absolute relationship between the four loci and the onset of schizophrenia, there still remains the possibilities if the more detailed and elaborated pedigree studies are done.

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