Clinical and Experimental Reproductive Medicine
- 제21권2호
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- Pages.201-206
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- 1994
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- 2233-8233(pISSN)
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- 2233-8241(eISSN)
중합효소연쇄반응을 이용한 다운증후군의 진단
Diagnosis of Down Syndrome Using PCR
- 김영태 (고려대학교 의과대학 산부인과학교실) ;
- 이희경 (고려대학교 의과대학 산부인과학교실) ;
- 임혜경 (고려대학교 의과대학 산부인과학교실) ;
- 김정현 (고려대학교 의과대학 산부인과학교실) ;
- 김선행 (고려대학교 의과대학 산부인과학교실) ;
- 구병삼 (고려대학교 의과대학 산부인과학교실) ;
- 주갑순 (고려대학교 의과대학 산부인과학교실) ;
- 이민수 (고려대학교 의과대학 정신과학교실)
- Kim, Young-Tae (Department of Obstetrics and Gynecology, College of Medicine, Korea University) ;
- Lee, Hee-Kyung (Department of Obstetrics and Gynecology, College of Medicine, Korea University) ;
- Lim, Hye-Kyung (Department of Obstetrics and Gynecology, College of Medicine, Korea University) ;
- Kim, Jung-Hyun (Department of Obstetrics and Gynecology, College of Medicine, Korea University) ;
- Kim, Sun-Haeng (Department of Obstetrics and Gynecology, College of Medicine, Korea University) ;
- Ku, Pyong-Sahm (Department of Obstetrics and Gynecology, College of Medicine, Korea University) ;
- Ju, Gap-Soon (Department of Obstetrics and Gynecology, College of Medicine, Korea University) ;
- Lee, Min-Soo (Department of Obstetrics and Psychiatry, College of Medicine, Korea University)
- 발행 : 1994.08.31
초록
Down syndrome is one of the major chromosomal anomalies in Korea. To decrease incidence of Down syndrome, antenatal diagnosis is essential. At present, antenatal diagnosis of Down syndrome is done by karyotyping from chorionic villus sampling, amniocentesis, and cordocentsis. All these methods have some problems such as a risk of abortion, a long waiting time, difficulties in sampling, and so on. The aim of study was to confirm that PCR(Polymerase Chain Reaction) using D21S11 primer could be a diagnostic tool for Down syndrome. PCR using D21S11 primers with
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