Clinical and Experimental Reproductive Medicine
- 제21권2호
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- Pages.137-147
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- 1994
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- 2233-8233(pISSN)
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- 2233-8241(eISSN)
인간 배아의 동결보존에 관한 연구
Cryopreservation of Human Embryos for Assisted Reproductive Technology
- 문신용 (서울대학교 의과대학 산부인과학교실) ;
- 김정훈 (서울대학교 의과대학 산부인과학교실) ;
- 김석현 (서울대학교 의과대학 산부인과학교실) ;
- 최영민 (서울대학교 의과대학 산부인과학교실) ;
- 신창재 (서울대학교 의과대학 산부인과학교실) ;
- 김정구 (서울대학교 의과대학 산부인과학교실) ;
- 이진용 (서울대학교 의과대학 산부인과학교실) ;
- 장윤석 (서울대학교 의과대학 산부인과학교실)
- Moon, Shin-Yong (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
- Kim, Chung-Hoon (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
- Kim, Seok-Hyun (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
- Choi, Young-Min (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
- Shin, Chang-Jae (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
- Kim, Jung-Gu (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
- Lee, Jin-Yong (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University) ;
- Chang, Yoon-Seok (Department of Obstetrics and Gynecology, College of Medicine, Seoul National University)
- 발행 : 1994.08.31
초록
Controlled ovarian hyperstimulation(COH) for in vitro fertilization and embryo transfer(IVFET) often results in the production of more embryos than can be efficaciously transferred at one time. However, embryo cryopreservation provides a mechanism by which additional embryos can be stored for later thawing and transfer. From November, 1990 to October, 1992, we completed 42 transfer cycles of cryopreserved pronucleus(PN) l-cell embryos using the fixed protocol of hormonal replacement therapy in a physiological manner regardless of individual ovarian function. Artificial endometrial stimulation was performed with only exogenous estradiol and progesterone(E-P) in 36 transfer cycles (Group I) and with gonadotropin-releasing hormone agonist(GnRHa) and exogenous estradiol and progesterone(GEEP) in 6 transfer cycles(Group II ). The results were as follows. 1. The Survival rate of total cryopreserved-thawed embryos was 64.9%(198/305): 64.9% (172/265) in Group I and 65.0% (26/40) in Group II. 2. Total 168 embryos were transferred with an average of 4.7 per ET in Group I and total 26 embryos were transferred with an average of 4.3 per ET in Group II. 3. The pregnancy rate(PR) per cryopreserved-thawed ET and the implantation rate was 33.3 %(14/42) and 6.7%(13/194), respectively. The PRs per cryopreserved-thawed ET were 30.6% (11/36) in Group I and 50.0% (3/6) in Group II without significant difference. 4. The take home baby rate was 11.1%(4/36) in Group I and 33.3% (2/6) in Group II.
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