Clinical and Experimental Reproductive Medicine
- Volume 21 Issue 3
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- Pages.241-245
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- 1994
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- 2233-8233(pISSN)
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- 2233-8241(eISSN)
Cotreatment with Growth Hormone in Controlled Ovarian Hyperstimulation for IVF in Women with Limited Ovarian Reserve
체외수정시술을 위한 성선자극호르몬 과배란유도에 Limited Ovarian Reserve를 갖는 환자에서 성장호르몬의 사용
- Kim, Sun-Haeng (Department of Obstetrics and Gynecology, Medical College, Korea University) ;
- Chang, Ki-Hoon (Department of Obstetrics and Gynecology, Medical College, Korea University) ;
- Ku, Pyoung-Sahm (Department of Obstetrics and Gynecology, Medical College, Korea University)
- Published : 1994.12.26
Abstract
Despite increasing success rate of IVF, poor response to ovarian stimulation remains a problem. So, attempts to improve ovarian responses, for example, by using combined gonadotropin-releasing hormone analogue(GnRH-a) and human menopausal gonadotropin(hMG) have shown limited success. It is reported that response of granulosa cells in vitro to FSH is stimulated by co-incubation with IGF-l, and IGF-l production can be increased by growth hormone. This suggest that combination regimen of G.H. and hMG may augment follicle recruitment. In fifteen patients who had previous history of poor ovarian response to gonadotropin stimulation after pituitary suppression with mid -luteal GnRH-a, the effectiveness of cotreatment with G.H. in IVF program was evaluated using a combination regimen of G.R. and hMG at Korea University Hospital IVF Clinic. Ovarian responses to gonadotropin stimulation in control and GH-treated cycles assessed by total dose and duration of hMG treatment, follicular development and peak
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