공업화학 (Applied Chemistry for Engineering)
- 제5권3호
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- Pages.501-508
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- 1994
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- 1225-0112(pISSN)
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- 2288-4505(eISSN)
Dextran에 결합된 새로운 Quinolone계 항균제의 개발
Development of New Quinolone Antibacterials with Dextran-bond
- Kim, Sun-Il (Dept. of Chem. Eng., Chosun Univ.) ;
- Na, Jae-Woon (Dept. of Chem. Eng., Chosun Univ.)
- 투고 : 1994.02.21
- 심사 : 1994.04.21
- 발행 : 1994.06.01
초록
방출조절성 약제를 개발하기 위한 방법으로 1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl)quitoline-3-carboxylic acid의
1-Ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl)quinolinea-3-car-boxylic acid-dextran was synthesized by the reaction of 1-ethyl-6-fluoro-1, 4-dihydro-4-oxo-7-(1-piperazinyl )quinoline-3-acryloyl chloride with dextran. Polymeric drug was tested for antimicrobial activity in vitro against ten species of microorganisms. Polymeric drug revealed good antibacterial activity against Bacillus subtillis ATCC 6633, Staphyloccus aureus ATCC 25923, Mycrobactertum phlei IFO 3158, Salmonella typhimurium KCTC 1925, Escherichia coli KCTC 1039, Escherichia coli ESS, Klebsiella puemouiae KCTC 1560 and Pseudomonas aeruginosa IFO 13130. Polymeric drug have no antimicrobial against Candida albicans ATCC 10231, but moderately active Micrococcus luteus ATCC 9341.
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