An Experimental Study on the Effects of Gungsindodamtang and Dangquibohyultang on the contents of Serotonin and Catecholamine in the Brain and the Plasma of the Reserpine treated rats

궁신도담탕(芎辛導痰湯) 및 당귀보혈탕(當歸補血湯)이 뇌(腦) 및 혈장(血漿)의 Serotonin과 Catecholamine 함량(含量)에 미치는 영향(影響)

This Study was performed to prove the effects of Gungsindodamtang (GDT) and Dangquibohyultang (DBT) on the cosntents of Serotonin and Catecholamine in the Brain and the Plasma of the Reserpine treated rats. High-Perfomance Liquid Chromatography was used for measuring the contents of the Serotonin and Catecholamine. The results were as follows. 1. norepinephrine contents in the Brain were increased significantly in GDT-treated group and DBT-treated group in comparison with the control group. 2. epinephrine and serotonin contents in the Brain were increased in all the sample groups but have not significance. 3. norepinephrine contents in the plasma were increased significantly in all the sample groups in comparison with the control group. 4. epinephrine contents in the plasma were increased in all the sample groups but have not significance. 5. serotonin contents in the plasma were increased significantly in DBT-treated group in comparison with the control group, and inreased in GDT-treated group but have not significance. According to the above results, it is considered that Dangquibohyultang could be applied more effectively than Gungsindodamtang in decrease of the serotonin and catecholamine and other symptoms induced by Reserpine.