Journal of Preventive Medicine and Public Health

The Korean Society for Preventive Medicine (대한예방의학회)
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A Case-Control Study of Primary Liver Cancer and Liver Disease History

간 질환력과 원발성 간암에 관한 환자-대조군 연구

  • Kim, Dong-Hyun (Departments of Preventive Medicine, Seoul National University College of Medicine) ;
  • Park, Byung-Joo (Departments of Preventive Medicine, Seoul National University College of Medicine) ;
  • Yoo, Keun-Young (Departments of Preventive Medicine, Seoul National University College of Medicine) ;
  • Ahn, Yoon-Ok (Departments of Preventive Medicine, Seoul National University College of Medicine) ;
  • Lee, Hyo-Suk (Departments of Internal Medicine, Seoul National University College of Medicine) ;
  • Kim, Chung-Yong (Departments of Internal Medicine, Seoul National University College of Medicine) ;
  • Lee, Sang-Il (Department of Preventive Medicine Ulsan University College of Medicine) ;
  • Lee, Moo-Song (Department of Preventive Medicine Ulsan University College of Medicine) ;
  • Ahn, Hyung-Sik (Department Preventive Medicine Chung-Buk National University College of Medicine) ;
  • Kim, Heon (Department Preventive Medicine Chung-Buk National University College of Medicine) ;
  • Park, Tae-Soo (Korea Medical Insurance Corporations)
  • 김동현 (서울대학교 의과대학 예방의학교실) ;
  • 박병주 (서울대학교 의과대학 예방의학교실) ;
  • 유근영 (서울대학교 의과대학 예방의학교실) ;
  • 안윤옥 (서울대학교 의과대학 예방의학교실) ;
  • 이효석 (서울대학교 의과대학 내과학교실) ;
  • 김정룡 (서울대학교 의과대학 내과학교실) ;
  • 이상일 (울산대학교 의과대학 예방의학교실) ;
  • 이무송 (울산대학교 의과대학 예방의학교실) ;
  • 안형식 (충북대학교 의과대학 예방의학교실) ;
  • 김헌 (충북대학교 의과대학 예방의학교실) ;
  • 박태수 (의료보험관리공단)
  • Published : 1994.06.01
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Abstract

The relationship between past liver disease history and the risk of primary liver cancer was analyzed in a hospital-based case-control study conducted in Seoul on 165 patients with histologically or serologically confirmed hepatocellular carcinoma and individually age- and sex-matched 165 controls in hospital for ophthalmologic, otologic, or nasopharyngeal problems. Significant association were observed for liver deseases occurring 5 or more years before liver cancer diagnosis [OR,4.9;95% confidence interval (CI), $1.6{\sim}14.0$) and family history of liver disease(OR, 9.0;95% CI, $2.1{\sim}38.8$). These associations were not appreciably modified by allowance for major identified potential confounding factors. From these results, it is possible to speculate that liver cell injuries caused by various factors might be a common pathway to developing primary liver carcinoma. Considering the significant effect of family history of liver diseases on PLCA risk after adjusting past liver disease history, there might be genetic susceptibility in the carcinogenic mechanism of liver cancer. Further investigations are needed to clarify the effect of family history of liver disease on PLCA risk.

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