Korean Journal of Veterinary Research (대한수의학회지)
- Volume 34 Issue 3
- /
- Pages.609-617
- /
- 1994
- /
- 2466-1384(pISSN)
- /
- 2466-1392(eISSN)
The carcinogenicity study of Folpet in rats
랫드에서 Folpet의 발암성에 관한 연구
-
Lee, Yong-soon
(College of Veterinary Medicine, Seoul National University) ;
- Cho, Jae-jin (College of Veterinary Medicine, Seoul National University) ;
-
Kang, Kyung-sun
(College of Veterinary Medicine, Seoul National University) ;
- Kim, Bae-hwan (College of Veterinary Medicine, Seoul National University) ;
-
Nam, Ki-hoan
(College of Veterinary Medicine, Seoul National University) ;
-
Seo, Kwang-won
(College of Veterinary Medicine, Seoul National University) ;
- Kang, Seong-keun (College of Veterinary Medicine, Seoul National University) ;
-
Lim, Yun-kyu
(Department of Veterinary Medicine, Cheju National University) ;
-
Heo, Kang-jun
(College of Veterinary Medicine, Chungbuk National University)
-
이영순
(서울대학교 수의과대학) ;
- 조재진 (서울대학교 수의과대학) ;
-
강경선
(서울대학교 수의과대학) ;
- 김배환 (서울대학교 수의과대학) ;
-
남기환
(서울대학교 수의과대학) ;
-
서광원
(서울대학교 수의과대학) ;
- 강성근 (서울대학교 수의과대학) ;
-
임윤규
(제주대학교 수의학과) ;
-
허강준
(충북대학교 수의과대학)
- Received : 1994.05.13
- Published : 1994.07.30
Abstract
This study was performed for assessing carcinogenicity of Folpet using medium-term carcinogenicity bioassay. Sprague-Dawley rats aged six weeks divided into four grout's and were initially given an intraperitoneal injection of diethylnirosamine at 200mg/kg body weight. Two weeks later, group 1(negative control) was treated with basal diet. A Folpet was given per oral administration to group 2(100 ppm) and goup 3(1,000 ppm). Group 4 was fed on water containing 0.05% phenobarbital sodium as a promtor for six weeks. At three weeks after beginning of the experiment, partial hepatectomy was performed in all rats. The tumor-promoting effects were examined by the numbers and areas per