Korean Journal of Veterinary Research (대한수의학회지)
- Volume 34 Issue 3
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- Pages.609-617
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- 1994
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- 2466-1384(pISSN)
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- 2466-1392(eISSN)
The carcinogenicity study of Folpet in rats
랫드에서 Folpet의 발암성에 관한 연구
- Lee, Yong-soon (College of Veterinary Medicine, Seoul National University) ;
- Cho, Jae-jin (College of Veterinary Medicine, Seoul National University) ;
- Kang, Kyung-sun (College of Veterinary Medicine, Seoul National University) ;
- Kim, Bae-hwan (College of Veterinary Medicine, Seoul National University) ;
- Nam, Ki-hoan (College of Veterinary Medicine, Seoul National University) ;
- Seo, Kwang-won (College of Veterinary Medicine, Seoul National University) ;
- Kang, Seong-keun (College of Veterinary Medicine, Seoul National University) ;
- Lim, Yun-kyu (Department of Veterinary Medicine, Cheju National University) ;
- Heo, Kang-jun (College of Veterinary Medicine, Chungbuk National University)
- 이영순 (서울대학교 수의과대학) ;
- 조재진 (서울대학교 수의과대학) ;
- 강경선 (서울대학교 수의과대학) ;
- 김배환 (서울대학교 수의과대학) ;
- 남기환 (서울대학교 수의과대학) ;
- 서광원 (서울대학교 수의과대학) ;
- 강성근 (서울대학교 수의과대학) ;
- 임윤규 (제주대학교 수의학과) ;
- 허강준 (충북대학교 수의과대학)
- Received : 1994.05.13
- Published : 1994.07.30
Abstract
This study was performed for assessing carcinogenicity of Folpet using medium-term carcinogenicity bioassay. Sprague-Dawley rats aged six weeks divided into four grout's and were initially given an intraperitoneal injection of diethylnirosamine at 200mg/kg body weight. Two weeks later, group 1(negative control) was treated with basal diet. A Folpet was given per oral administration to group 2(100 ppm) and goup 3(1,000 ppm). Group 4 was fed on water containing 0.05% phenobarbital sodium as a promtor for six weeks. At three weeks after beginning of the experiment, partial hepatectomy was performed in all rats. The tumor-promoting effects were examined by the numbers and areas per