Asian-Australasian Journal of Animal Sciences
- 제7권1호
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- Pages.119-124
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- 1994
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- 1011-2367(pISSN)
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- 1976-5517(eISSN)
DOI QR Code
DIFFERENTIAL EXPRESSION OF ORNITHINE DECARBOXYLASE AND HA-RAS CELLULAR ONCOGENE DURING DEVELOPMENT OF THE FEMALE RAT
- Baik, M.G. (Department or Genctic Engineering, Chonnam National University) ;
- Park, C.S. (Laboratory of Growth/Lactation, Department or Animal and Range Science, North Dakota State University)
- 투고 : 1993.05.19
- 심사 : 1993.10.28
- 발행 : 1994.03.01
초록
Experiments were performed to determine age-associated changes in ornithine decarboxylase (ODC) gene and Ha-ras cellular oncogene expression in tissues of female rats. In the kidney, ODC mRNA levels did not show age-associated changes, while ODC enzyme activities were decreased with advancing age from 3 to 10 months. These results suggest that post-transcriptional mechanism (s) are involved in the age-dependent decrease in renal ODC enzyme activity. In addition, we found no correlation between testosterone-induced renal ODC expression and DNA methylation pattern. Ha-ras mRNA levels in brain decreased as animals aged from 3 to 6 months, while renal Ha-ras mRNA levels were not influenced by age. Results demonstrate the age-dependent expression of Ha-ras in a tissue-specific manner.